The effect of the cut surface during electrical stimulation of a cardiac wedge preparation

Author

Roth, Bradley J. ; Patel, Salil G. ; Murdick, Ryan A.

Author_Institution

Dept. of Phys., Oakland Univ., Rochester, MI, USA

Volume

53

Issue

6

fYear

2006

fDate

6/1/2006 12:00:00 AM

Firstpage

1187

Lastpage

1190

Abstract

Optical mapping from the cut surface of a "wedge preparation" allows observation inside the heart wall, below the epicardium or endocardium. We use numerical simulations based on the bidomain model to illustrate how the transmembrane potential is influenced by the cut surface. The distribution of transmembrane potential around a unipolar cathode depends on the fiber angle. For intermediate angles, hyperpolarization appears on only one side of the electrode, and is large and widespread.

Keywords

bioelectric potentials; biomedical optical imaging; biomembranes; cardiology; physiological models; bidomain model; cardiac wedge Preparation; cut surface effect; electrical stimulation; endocardium; epicardium; heart wall; hyperpolarization; optical mapping; transmembrane potential; unipolar cathode; Cardiac tissue; Electrical stimulation; Electrodes; Geometry; Heart; Numerical simulation; Optical fiber polarization; Optical recording; Physics; Stimulated emission; Bidomain; cardiac; electrical stimulation; fiber geometry; wedge preparation; Action Potentials; Animals; Artifacts; Body Surface Potential Mapping; Cardiac Pacing, Artificial; Cells, Cultured; Computer Simulation; Diagnosis, Computer-Assisted; Electric Stimulation Therapy; Heart Conduction System; Humans; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Tissue Culture Techniques;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2006.873386

Filename

1634513