Title :
The effect of the cut surface during electrical stimulation of a cardiac wedge preparation
Author :
Roth, Bradley J. ; Patel, Salil G. ; Murdick, Ryan A.
Author_Institution :
Dept. of Phys., Oakland Univ., Rochester, MI, USA
fDate :
6/1/2006 12:00:00 AM
Abstract :
Optical mapping from the cut surface of a "wedge preparation" allows observation inside the heart wall, below the epicardium or endocardium. We use numerical simulations based on the bidomain model to illustrate how the transmembrane potential is influenced by the cut surface. The distribution of transmembrane potential around a unipolar cathode depends on the fiber angle. For intermediate angles, hyperpolarization appears on only one side of the electrode, and is large and widespread.
Keywords :
bioelectric potentials; biomedical optical imaging; biomembranes; cardiology; physiological models; bidomain model; cardiac wedge Preparation; cut surface effect; electrical stimulation; endocardium; epicardium; heart wall; hyperpolarization; optical mapping; transmembrane potential; unipolar cathode; Cardiac tissue; Electrical stimulation; Electrodes; Geometry; Heart; Numerical simulation; Optical fiber polarization; Optical recording; Physics; Stimulated emission; Bidomain; cardiac; electrical stimulation; fiber geometry; wedge preparation; Action Potentials; Animals; Artifacts; Body Surface Potential Mapping; Cardiac Pacing, Artificial; Cells, Cultured; Computer Simulation; Diagnosis, Computer-Assisted; Electric Stimulation Therapy; Heart Conduction System; Humans; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Tissue Culture Techniques;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2006.873386
