When messages are transmitted as blocks of binary digits, means of locating the beginnings of blocks are provided to keep the receiver in synchronism with the transmitter. Ordinarily, one uses a special synchronizing symbol (which is really a third kind of digit, neither 0 nor 1) for this purpose. The Morse code letter space and the teletype start and stop pulses are examples. If a special synchronizing digit is not available, its function may be served by a short sequence of binary digits

which is placed as a prefix to each block. The other digits must then be constrained to keep the sequence

from appearing within a block. If blocks of

digits (including the prefix

) are used, the prefix should be chosen to make large the number

of different blocks which satisfy the constraints. Lengthening the prefix decreases the number of "message digits" which remain in the block but also relaxes the constraints. Thus, for each

, there corresponds some optimum length of prefix. For each prefix

, a generating function, a recurrence formula, and an asymptotic formula for large

are found for

. Tables of

are given for all prefixes of four digits or fewer. Among all prefixes

of a given length

, the one for which

has the most rapid growth is

. However, for this choice of

, the table of values of

starts with small values;

does not become the best

-digit prefix until

is very large. At these values of

, the

digit prefix

is still better. The tables suggest that, for any

, a best prefix can always be found in the form

, for suitable

. Taking

and
![A = [\\log _2 (N \\log _2 e)]](/images/tex/4726.gif)
it is shown that

is roughly

. This result is near optimal since no choice of

can make

exceed

.