Modelling of processes governing subcellular localisation of MinD in Escherichia coli

Recent research has highlighted several examples wherein bacterial cell fate is determined by precise subcellular localisation of proteins. A prominent example is the polar localisation and oscillation of the Min proteins which is necessary for accurate cell division in Escherichia coli. Several computational models have been proposed which reproduce the oscillatory behaviour and observed phenotypes. However, these models use varying assumptions to do so leading to different mechanisms for precise polar localisation of MinD zones. To gain further insight, the authors extend a simplified model which focused on some key processes to explain the observed length scale for MinD zone formation. Using analytical approaches and numerical simulations, the authors explore cellular MinD distributions produced by these processes and propose a mechanism for precise polar localisation of MinD.