IC/microfluidic hybrid system for magnetic manipulation of biological cells

Author

Lee, Hakho ; Liu, Yong ; Westervelt, Robert M. ; Ham, Donhee

Author_Institution

Dept. of Phys., Harvard Univ., Cambridge, MA, USA

Volume

41

Issue

6

fYear

2006

fDate

6/1/2006 12:00:00 AM

Firstpage

1471

Lastpage

1480

Abstract

This paper introduces an integrated circuit (IC)/microfluidic hybrid system for magnetic manipulation of biological cells. The hybrid system consists of an IC and a microfluidic system fabricated on top. Biological cells attached to magnetic beads are suspended inside the microfluidic system that maintains biocompatibility. The IC contains a microcoil array circuit that produces spatially-patterned microscopic magnetic fields. Programmable, rapid reconfiguration of the field pattern made possible by the IC allows an efficient simultaneous manipulation of multiple individual bead-bound cells with precise position control. Two prototypes, SiGe/microfluidic and CMOS/microfluidic hybrid systems, validate the proposed approach.

Keywords

CMOS logic circuits; array signal processing; biological techniques; hybrid integrated circuits; microfluidics; position control; CMOS; SiGe; bioelectronics; biological cells; digital logic; integrated circuits; magnetic manipulation; microcoil array circuit; microfluidic hybrid system; position control; Biological cells; Hybrid integrated circuits; Magnetic circuits; Magnetic fields; Magnetic force microscopy; Magnetic levitation; Microfluidics; Position control; Prototypes; Silicon germanium; Bioelectronics; CMOS integrated circuits; SiGe integrated circuits; biolab-on-IC; cell manipulations; digital logic; integrated circuits; lab-on-a-chip; microcoil arrays; microcoils; microfluidics;

fLanguage

English

Journal_Title

Solid-State Circuits, IEEE Journal of

Publisher

ieee

ISSN

0018-9200

Type

jour

DOI

10.1109/JSSC.2006.874331

Filename

1637611