ﺗﺄﺛﯿﺮ ﺣﺎد ﻓﻌﺎﻟﯿﺖ ﺗﺪاوﻣﯽ و ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ ﺑﺮ ﺳﻄﻮح ﭘﻼﺳﻤﺎﯾﯽ اﯾﯽ ـ ﺳﻠﮑﺘﯿﻦ و ﺷﺎﺧﺺﻫﺎي ﮔﻠﺒﻮلﻫﺎي ﺳﻔﯿﺪ در ﺑﯿﻤﺎران ﻋﺮوق ﮐﺮوﻧﺮ

Acute Effects of Continuous or High Intensity Interval Exercise on Plasma Levels of E-Selectin and WBC Indices in CHD Patients

ﻫﺪف از ﭘﮋوﻫﺶ ﺣﺎﺿﺮ، ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮ ﺣﺎد ﻓﻌﺎﻟﯿﺖ ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ و ﺗﺪاوﻣﯽ ﺑﺮ ﺳﻄﻮح ﭘﻼﺳﻤﺎﯾﯽ اﯾﯽ ـ ﺳﻠﮑﺘﯿﻦ و ﺷﺎﺧﺺﻫﺎي ﮔﻠﺒﻮلﻫﺎي ﺳﻔﯿﺪ در ﺑﯿﻤﺎران ﻋﺮوق ﮐﺮوﻧﺮ ﺑﻮد. ﺑﺪﯾﻦﻣﻨﻈﻮر، از ﺑﯿﻦ ﺑﯿﻤﺎران ﻗﻠﺒﯽ ﻣﺮد داوﻃﻠﺐ ﺑﺎ ﺳﺎﺑﻘﮥ ﻋﻤﻞ ﺟﺮاﺣﯽ ﺑﺎيﭘﺲ و اﺳﺘﻨﺖﮔﺬاري، 30 ﺑﯿﻤﺎر اﻧﺘﺨﺎب ﺷﺪﻧﺪ و در ﺳﻪ ﮔﺮوه ﮐﻨﺘﺮل، ﺗﻤﺮﯾﻦ ﺗﺪاوﻣﯽ و ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ ﺟﺎي ﮔﺮﻓﺘﻨﺪ. ﻓﻌﺎﻟﯿﺖ ﺗﻨﺎوﺑﯽ ﺷﺎﻣﻞ: ﮔﺮمﮐﺮدن، ﻫﺸﺖ ﺗﮑﺮار ﭼﻬﺎر دﻗﯿﻘﻪاي ﻓﻌﺎﻟﯿﺖ )دو دﻗﯿﻘﻪ ﻓﻌﺎﻟﯿﺖ ﺑﺎ ﺷﺪت 90 درﺻﺪ اوج اﮐﺴﯿﮋن ﻣﺼﺮﻓﯽ و دو دﻗﯿﻘﻪ اﺳﺘﺮاﺣﺖ ﻓﻌﺎل ﺑﺎ ﺷﺪت 30 درﺻﺪ اوج اﮐﺴﯿﮋن ﻣﺼﺮﻓﯽ( و ﺳﺮدﮐﺮدن ﺑﻮد. ﻓﻌﺎﻟﯿﺖ ﺗﺪاوﻣﯽ ﻧﯿﺰ درﺑﺮﮔﯿﺮﻧﺪة 30 دﻗﯿﻘﻪ ﻓﻌﺎﻟﯿﺖ ﺑﺎ ﺷﺪت 60 درﺻﺪ اوج اﮐﺴﯿﮋن ﻣﺼﺮﻓﯽ ﺑﻮد. ﻧﻤﻮﻧﻪﻫﺎي ﺧﻮﻧﯽ ﻗﺒﻞ و ﺑﻌﺪ از ﻓﻌﺎﻟﯿﺖ ﺟﻤﻊآوري ﺷﺪه و ﺑﺮاي اﻧﺪازهﮔﯿﺮي اﯾﯽ ـ ﺳﻠﮑﺘﯿﻦ و ﺷﺎﺧﺺﻫﺎي ﮔﻠﺒﻮلﻫﺎي ﺳﻔﯿﺪ آﻧﺎﻟﯿﺰ ﮔﺮدﯾﺪﻧﺪ. از وارﯾﺎﻧﺲ ﯾﮏراﻫﻪ و ﻫﻢﺑﺴﺘﮕﯽ ﭘﯿﺮﺳﻮن ﺑﺮاي ﺗﺤﻠﯿﻞ آﻣﺎري دادهﻫﺎ اﺳﺘﻔﺎده ﺷﺪ.ﻧﺘﺎﯾﺞ ﻧﺸﺎن ﻣﯽدﻫﺪﮐﻪ ﺑﯿﻦ اﻓﺰاﯾﺶ اﯾﯽـ ﺳﻠﮑﺘﯿﻦ در ﺳﻪ ﮔﺮوه ﺗﻔﺎوت ﻣﻌﻨﺎداري وﺟﻮد دارد(0.001p). ﺑﻪﻃﻮرﮐﻠﯽ، ﯾﮏ ﺟﻠﺴﻪ ﻓﻌﺎﻟﯿﺖ ورزﺷﯽ ﺑﺮاي ﺑﯿﻤﺎران ﻋﺮوق ﮐﺮوﻧﺮ ﺑﺎﻋﺚ ﺗﺤﺮﯾﮏ ﻣﺴﯿﺮﻫﺎي اﻟﺘﻬﺎﺑﯽ و اﻓﺰاﯾﺶ ﺷﺎﺧﺺﻫﺎي اﻟﺘﻬﺎﺑﯽ در ﺑﺪن ﻣﯽﺷﻮد ﮐﻪ ﺑﺎ اﻓﺰاﯾﺶ ﺷﺪت ﻓﻌﺎﻟﯿﺖ ﺑﻪواﺳﻄﮥ ﻓﻌﺎﻟﯿﺖ ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ، اﯾﻦ ﭘﺎﺳﺦ اﻓﺰاﯾﺶ ﻣﯽﯾﺎﺑﺪ؛ ﻟﺬا، اﺳﺘﻔﺎده از اﯾﻦ ﻓﻌﺎﻟﯿﺖﻫﺎ ﺑﺮاي ﯾﮏ ﺟﻠﺴﻪ در ﺑﯿﻤﺎران ﻗﻠﺒﯽ ﭘﯿﺸﻨﻬﺎد ﻧﻤﯽﺷﻮد.

The aim of this study was to investigate the acute effects of continuous or high intensity interval exercise on plasma E-Selectin and WBC indices in CHD patients. Therefore, 30 male heart patients with Coronary Artery Bypass (CABG) and stenting (PCI) history voluntarily participated and divided into three groups: control, continuous and high-intensity interval (HIIT) group. Patients of HIIT group performed 8 repetitions of a 4-min interval training (2:2 min exercise: recovery, intensity: 90:30 %VO2peak), but continuous group performed a 30-min continuous exercise with a constant intensity at 60 %VO2peak. Blood samples were taken before and after exercise and their E-selectin and WBC indices were analyzed. The one-way ANOVA and Pearson correlation were used for statistical analysis. The results showed significant differences between the three groups for E-selectin increase (F2, 27=27.8, P<0.001). Bonferroni post hoc test has showed significant differences between control and interval (P=0.001), control and continuous (P=0.001) and also continuous and interval groups (P=0.009) in amount of increment. But no significant changes were observed in WBC indices responses between groups (P>0.05). It can be concluded that a session of exercise may stimulate the inflammation related processes that may be exacerbate in CABG and PCI patients by HIIT. Thus, using this type of exercise for just one session is not recommended in heart patients.