بررسي سطح پلاسمايي ويتامين D در مبتلايان به ژيارديازيس مزمن مراجعه كننده به آزمايشگاه بيمارستان‌هاي آموزشي دانشگاه علوم پزشكي جندي شاپور اهواز و احتمال خطر ابتلاء به ديابت نوع 2 در اين افراد

Effect of Chronic Giardiasis on the Status of Vitamin D and the Risk of Development Type2 Diabetes in Patients Referring to the Clinical Laboratory of Educational Hospitals of Ahvaz Jundishapur University of Medical Sciences

زمينه و هدف: ژيارديازيس يك بيماري انگلي ايجاد توسط ژيارديا لامبليا است كه باعث سوء جذب ويتامين D شده و كمبود اين ويتامين احتمال ابتلا به ديابت نوع 2 را افزايش مي دهد. بنابراين مطالعه حاضر با هدف بررسي اثر ژيارديازيس مزمن بر وضعيت ويتامين D و خطر ابتلاء به ديابت نوع 2 در بيماران صورت پذيرفت. روش بررسي: در مطالعه مورد شاهدي (Case-Control) حاضر تعداد 60 نفراز مراجعين به آزمايشگاه بيمارستان هاي آموزشي دانشگاه علوم پزشكي جندي شاپور اهواز بررسي شدند. پس از تاييد آلودگي به انگل ژيارديا به روش مسقيم و خونگيري از بيماران، نمونه‌ها بدست آمده، سپس پلاسما جدا شده و مقادير ويتامينD، گلوكز، انسولين ، فاكتورهاي ليپيدي و آنزيم‌هاي كبدي، شاخص‌هاي مقاومت به انسولين (HOMA-IR) ، عملكرد سلول هاي بتا (HOMA-β) و بررسي حساسيت به انسولين (QUICKI) مورد سنجش قرار گرفتند. يافته ها: سطح پلاسمايي ويتامين D در گروه بيمار نسبت به افراد سالم كاهش يافت (P <0.05). اگر چه انسولين و پروفايل ليپيدي پلاسما در اين بيماران تغيير معني داري ننمود اما گلوكز (0/001

Background and Objective: Giardiasis is a parasitic disease produced by Giardia lamblia can lead to malabsorption of vitamin D and in turn, deficiency of this vitamin increases the risk of development of type 2 diabetes. The objective of the present study was to investigate the effect of chronic Giardiasis on the status of vitamin D and the risk of type2 diabetes in patients suffering from chronic giardiasis. Subjects and Methods: Sixty patients referred to the clinical laboratories of the educational hospitals of Ahvaz Jundishapur University of Medical Sciences were voluntarily enrolled in this case-control study. After confirmation of giardia parasite infection by direct and blood sampling from patients, plasma sample was isolated, and the levels of vitamin D, glucose, insulin, lipid factors, liver enzymes were evaluated. In addition, the insulin resistance index (HOMA-IR), beta-cell function index (HOMA-β), insulin sensitivity index (QUICKI) were assessed. Furthermore, the liver enzymes (AST, ALT and ALP) were determined for both groups. Results: Plasma level of vitamin D in patients with giardiasis was significantly lower than healthy subjects (P <0.05). Although insulin level did not increase in these patients, glucose (P<0.001) and HOMA-IR (P<0.05) increased significantly in these patients. While HOMA-β, QUICKI and DI decreased significantl in patients with giardiasis (P <0.05). The values of AST (P <0.001), ALT (P <0.01) and ALP (P <0.05) enzymes were significantly higher in patients with giardiasis. Conclusion: The overall result of this study indicates that chronic giardiasis leads to a decrease in vitamin D level and an increase in the variables related to type2 diabetes. In addition, there are direct correlation between both chronic giardiasis and decrease in vitamin D and the increase in activity of liver enzymes.