پاسخ‌هاي التهابي كودكان كوتاه قد مبتلا به اديوپاتي به 2 هفته بي فعاليتي پس از يك دوره فعاليت بدني

INFLAMMATORY RESPONSES OF CHILDREN WITH IDIOPATHIC SHORT STATURE TO TWO WEEKS OF INACTIVITY AFTER THE ONE PERIOD OF PHYSICAL ACTIVITY

هدف تحقيق: فعاليت بدني يك عامل مهم تقويت سيستم ايمني و كاهش عوامل التهابي است كه مي‌تواند رشد را با تاثير بر واسطه‌هاي آنابوليك و كاتابوليك، گسترش دهد. اين مطالعه با هدف بررسي پاسخ‌هاي التهابي كودكان كوتاه قد مبتلا به اديوپاتي به 2 هفته بي فعاليتي پس از يك دوره فعاليت بدني انجام شد. روش تحقيق: اين پژوهش نيمه تجربي در جامعه كودكان مراجعه كننده به كلينيك غدد بيمارستان آتيه شهر تهران انجام شد . چهارده كودك مبتلا به كوتاه قدي ايديوپاتي (4 دختر و 10 پسر) انتخاب و به صورت تصادفي به دو گروه تجربي و كنترل تقسيم شدند. آزمودني‌ها در گروه تجربي به مدت هشت هفته و هر هفته سه جلسه و هر جلسه به مدت 60 دقيقه به فعاليت بدني پرداختند. شدت فعاليت بدني 40-60 درصد حداكثر تواتر قلبي بود. سطوح سرمي IL-6، TNF-α و IL-1β قبل و بعد از هشت هفته فعاليت بدني و بعد از دو هفته بي فعاليتي سنجيده شد. داده‌ها با استفاده از آزمون تي مستقل و اندازه گيري‌هاي مكرر تحليل شدند. نتايج: يافته‌هاي مطالعه افزايش غير معني‌دار مقادير IL-6 و كاهش غير معني‌دار مقادير IL-1β را بعد از هشت هفته نشان داد (05/0

background and aim: physical activity is an important factor in improving the immune system and decreasing inflammatory agents, which can expand the growth by influencing anabolic and catabolic mediators. This study is being done with the purpose of determine inflammatory responses of children with idiopathic short stature to two weeks inactivity after the one period of physical activity. Materials and Methods: this semi-experimental study was conducted on the population of children attending to endocrine clinic of Atieh hospital of Tehran.14 idiopathic short stature children (4 girls, 10 boys) were randomly divided into control and experimental groups. Experimental group performed eight weeks, three sessions each week and each session 60 minutes. The intensity of physical activity was 40-60% of HRmax. IL-6, TNF-a and IL-1b were also measured before and after eight weeks of physical activity and after two weeks inactivity. Data were analyzed by kolmogorov-smirnov, independent t test and one-way ANOVA with repeated measures. Results: The result indicate that after eight weeks of physical activity, IL-6 increased insignificantly and IL-1b decreased insignificantly (p>0.05). Also, following two weeks of inactivity after eight weeks, inflammatory cytokines TNF-a, IL-1b decrease and IL-6 increase, but this changes were not significant (p>0.05). There was a significant difference between groups in the TNF-a (P=0.005) response after two weeks of inactivity. Conclusion: It seems that some positive effects of physical activity remain even after two weeks of inactivity. Therefore, in order to determine the required time for the inflammatory cytokines to be increased, researches with workout cycles longer than eight weeks are needed.