مقايسه سطح سرمي آنتي تيروئيد پراكسيداز در افراد سالم و بيماران مبتلا به افسردگي - مطالعه مورد شاهدي

Comparison of Anti Thyroid Peroxidase Antibody (TPOAb) levels in people with depression and healthy people: case control-study

زمينه و هدف افسردگي شايعترين اختلال روانپزشكي است كه در خانواده افراد نظامي نيز اين شيوع بالا است. اخيرا رابطه افسردگي با برخي از هورمون ها مورد توجه قرار گرفته است. در اين مطالعه سطح سرمي آنتي تيروئيد پروكسيداز، و هورمون محرك آزاد شدن تيروئيد (TSH)، تيروكسين (T4) و تري يدو تيرونين (T3) بيماران با تشخيص افسردگي و گروه كنترل سالم مقايسه شد. روش ها در اين مطالعه مورد شاهدي، 45 بيمار ارجاع شده به يك بيمارستان نظامي در شهر تهران كه افسردگي آنها بر اساس معيار هاي بك و DSM5 تشخيص داده شده بود و 45 فرد سالم از نظر سن و جنس همسان شدند. سطح سرمي آنتي تيروئيد پروكسيداز، T3, T4, TSH در دو گروه اندازه گيري و مقايسه شدند. نتيجه گيري با توجه به اينكه دو گروه سالم و افسرده از جهت وجود آنتي بادي آنتي پراكسيداز تفاوتي با يكديگر ندارند، لذا به نظر مي رسد كه آنتي بادي آنتي پراكسيداز در ايجاد يا شدت افسردگي نقشي ندارد.

Background and Aim: Depression is a common psychiatric disorder with a high prevalence in military personnel. Recently, the relationship between depression and some hormones has been reported. In current study, the serum levels of anti-thyroid peroxidase (anti-TPO), triiodothyronine (T3), thyroxin (T4) and thyroidstimulating hormone (TSH) was assessed in people with depression and compared with healthy control adults. Methods: In this case–control study, 45 people with depression who were diagnosed using the Beck depression test and DSM5, were referred to a military hospital. A total of 45 healthy participants who were matched according gender and age with the depression group, were also enrolled. Levels of anti-TPO, T4, T3 and TSH were measured and compared in the two groups. Results: The mean ±standard deviation age was 36.55±11.42 years in the case group and 35.92±11.58 years in the matched control group. There was no significant difference in the mean serum level of antithyroid peroxidase, T3, T4 and TSH between the groups (P≥0.05). There was no linear correlation between antithyroid peroxidase levels and depression severity. Conclusion: As there was not difference regarding anti-TPO antibody levels between the depressed and healthy groups, it appears that anti-TPO antibody may not have a role in depression.