كليدواژه :
تمرين تركيبي , ويتامين دي , ويسفاتين , مقاومت به انسولين , ديابت
چكيده لاتين :
Abstract
Background and Aim: Visfatin is an insulin-like protein derived from adipose tissue that is associated with obesity and insulin resistance. The purpose of this study was to compare the effects of 12 weeks of combined exercises and vitamin D on the serum visfatin level and beta cell function in women with overweight type II diabetes.
Methods: 40 type 2 diabetic women with a mean age of 1.49 ± 3.65 years, weight 158.15 ± 5.65 cm and body weight index 29.4 ± 0.46 kg / m2 were selected purposefully The groups were randomly divided into four groups of 10, three experimental groups (combined exercise, vitamin D, combined exercise with vitamin D) and control group. Height, weight, BMI and fat percentage of subjects were measured. After 12 hours of fasting, the primary blood sample was taken to measure glucose, insulin, visfatin, insulin resistance, and beta cell function. Subjects then participated in the experimental group 1 in the combined program. The experimental group, in addition to the combined exercises, consumed vitamin D 6 pills per 50,000 units a week. Experimental group 3 consumed only vitamin D with 6 pills per dose of 50,000 units per week and did not have any training. The control group was only tracked. After 12 weeks, all variables were re-measured in 4 groups. Data were analyzed using covariance analysis (ANCOVA) at the level of p <0.05.
Results: The mean values of post glucose, insulin, insulin resistance, beta cell and visfatin function were significantly different between the four groups with control of pre-test values of these variables (0.001> p). In the case of insulin, there was no significant difference between the mean values of insulin levels in vitamin D, exercise and combination therapy and vitamin D (p <0.05). There was no significant difference in insulin resistance between the mean resistance to insulin in the control and vitamin D groups (p> 0.05). There was no significant difference in the performance of beta cells between the mean values of performance in control, exercise and exercise groups and vitamin D (p <0.05). In the case of visfatin, the mean values of visfatin in the treatment group and vitamin D were significantly less than the other three groups (p <0.05).
Conclusion: The findings of this study indicate the effect of combined exercises and vitamin D intake on visfatin levels in overweight diabetic women.
