عوامل زمينه ساز سرطان التهابي پستان

The Baseline Causes of Inflammatory Breast Cancer

ﺍﻧﺠﻤﻦ ﺳﺮﻃﺎﻥ ﺁﻣﺮﻳﮑﺎ ﺑﻪ ﻃﻮﺭ ﺗﺨﻤﻴﻨﻲ ﺍﻋﻼﻡ ﮐﺮﺩﻩ ﺍﺳﺖ ﮐﻪ ﺳﺎﻻﻧﻪ 200 ﻫﺰﺍﺭ ﺧﺎﻧﻢ ﺑﻪ ﺳﺮﻃﺎﻥ ﭘﺴﺘﺎﻥ ﻣﺒﺘﻼ ﻣﻲﺷﻮﻧﺪ ﮐﻪ ﺩﺭ ﺍﻳﻦ ﻣﻴﺎﻥ 1 -7 ﺩﺭﺻﺪ ﺁﻧﺎﻥ ﻣﺒﺘﻼ ﺑﻪ ﻣﻬﺎﺟﻢﺗﺮﻳﻦ ﻧﻮﻉ ﺁﻥ ﻳﻌﻨﻲ ﺳﺮﻃﺎﻥ ﺍﻟﺘﻬﺎﺑﻲ ﭘﺴﺘﺎﻥ ﻫﺴﺘﻨﺪ. ﺩﺭ ﺍﻳﺮﺍﻥ ﺳﺮﻃﺎﻥ ﭘﺴﺘﺎﻥ ﺷﺎﻳﻌﺘﺮﻳﻦ ﺳﺮﻃﺎﻥ ﺩﺭ ﺑﻴﻦ ﺯﻧﺎﻥ ﻣﻲﺑﺎﺷﺪ ﻭ 21/4 ﺩﺭﺻﺪ ﺍﺯ ﺗﻤﺎﻣﻲ ﺳﺮﻃﺎﻥﻫﺎﻱ ﺯﻧﺎﻥ ﺭﺍ ﺷﺎﻣﻞ ﻣﻲﺷﻮﺩ. ﻋﻮﺍﻣﻞ ﻣﺤﻴﻄﻲ ﻭ ﮊﻧﺘﻴﮏ ﺩﺭ ﺍﻳﺠﺎﺩ ﺍﻳﻦ ﺑﻴﻤﺎﺭﻱ ﻧﻘﺶ ﻣﻬﻤﻲ ﺩﺍﺭﻧﺪ ﮐﻪ ﻣﻲﺗﻮﺍﻥ ﺍﺯ ﺷﺮﺍﻳﻂ ﻣﺤﻴﻄﻲ ﻣﺆﺛﺮ، ﺍﻓﺰﺍﻳﺶ ﺳﻦ، ﻭﺿﻌﻴﺖ ﺍﻗﺘﺼﺎﺩﻱ ﺍﺟﺘﻤﺎﻋﻲ ﻭ ﺍﺯ ﻋﻮﺍﻣﻞ ﮊﻧﺘﻴﮑﻲ، ﻧﮋﺍﺩ ﻭ ﺟﻬﺶ ﺭﺍ ﻧﺎﻡ ﺑﺮﺩ. ﺑﻌﻀﻲ ﺳﺮﻃﺎﻥﻫﺎﻱ ﺍﻟﺘﻬﺎﺑﻲ ﺍﺯ ﻧﻮﻉ ﻣﺠﺮﺍﻳﻲ ﻣﻬﺎﺟﻢ ﻫﺴﺘﻨﺪ. ﺗﺸﺨﻴﺺ ﺍﻳﻦ ﻧﻮﻉ ﺧـﺎﺹ ﺍﺯ ﺳﺮﻃﺎﻥ ﭘﺴﺘـﺎﻥ ﺑﻪ ﻃـﻮﺭ ﺍﺧـﺺ ﺑﻪ ﺻﻮﺭﺕ ﮐﻠﻴﻨﻴـﮑﻲ ﺍﺳﺖ. ﻣﺎﻣـﻮﮔـﺮﺍﻓﻲ، ﺳﻮﻧﻮﮔﺮﺍﻓﻲ، PET/CT ،MRI ﺍﺯ ﺟﻤﻠﻪ ﺭﻭﺵﻫﺎﻱ ﺗ ﺸﺨﻴﺼﻲ ﺩﺭ ﺳﺮﻃﺎﻥ ﺍﻟﺘﻬـﺎﺑﻲ ﭘﺴﺘﺎﻥ ﻫﺴﺘﻨﺪ ﮐﻪ ﻫﺮ ﮐﺪﺍﻡ ﺍﻃﻼﻋﺎﺗﻲ ﺩﺭ ﺯﻣﻴﻨﻪﺍﻱ ﺧﺎﺹ ﺩﺭ ﺍﺧﺘﻴـﺎﺭ ﻣﺎ ﻗـﺮﺍﺭ ﻣﻲﺩﻫﺪ. ﺍﻣﺮﻭﺯﻩ ﭘﻴﺸﺮﻓﺖﻫﺎﻳﻲ ﺩﺭ ﺍﺭﺗﺒﺎﻁ ﺑﺎ ﺭﻭﻳﮑـﺮﺩﻫﺎﻱ ﺩﺭﻣﺎﻧﻲ ﺁﻥ ﺍﻋﻢ ﺍﺯ ﺷﻴﻤﻲ ﺩﺭﻣﺎﻧﻲ ﻗﺒﻞ ﺍﺯ ﻋﻤﻞ ﺷﺪﻩ ﺍﺳﺖ ﮐﻪ ﻣﺸﺨﺼـﺎﹰ ﺑﻘﺎﻱ ﺑﻴﻤﺎﺭﺍﻥ ﺳﺮﻃﺎﻥ ﺍﻟﺘﻬﺎﺑﻲ ﭘﺴﺘﺎﻥ ﺭﺍ ﺍﻓﺰﺍﻳﺶ ﺩﺍﺩﻩ ﺍﺳﺖ.

The American Cancer Society has announced that approximately 200,000 women are diagnosed with breast cancer annually .Among which %1-%7 are diagnosed with the most invasive breast cancer type; the Inflammatory Breast Cancer. In Iran, breast cancer is the commonest cancer among women comprising 21.4% of all cancers among females. Environmental factors and genetic susceptibility play an important role in causing breast cancer. The environmental factors include: aging, and socioeconomic status and the genetic factors include: race, mutation and repetition. Some inflammatory breast cancers are the invasive ductile type. The diagnosis of this particular breast cancer is specifically determined clinically. Sonography, MRI, PET/CT and Mammography are common ways to diagnose this type of breast cancer. They provide us with specific information in regards to inflammatory breast cancer. Generally inflammatory breast cancer is fatal but recent improvement in therapeutic approach like Pre- Surgical Chemotherapy has significantly increased the survival rate