ﺗﺄﺛﯿﺮ ﺗﻤﺮﯾﻦ ﻫﻮازي ﺑﺮ ﺳﻄﻮح ﺳﺮﻣﯽ آدﯾﭙﻮﻧﮑﺘﯿﻦ و CRP و ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ در زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪروم ﻣﺘﺎﺑﻮﻟﯿﮏ

The Effect of Aerobic Exercise on Serum Levels of Adiponectin and CRP and Insulin Resistance in Women with Metabolic Syndrome

دﯾﭙﻮﻧﮑﺘﯿﻦ، آدﯾﭙﻮﮐﺎﯾﻨﯽ ﺑﺎ ﺗﺄﺛﯿﺮات ﺿﺪاﻟﺘﻬﺎﺑ ﯽ و ﺿﺪ ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧ ﺴﻮﻟﯿﻨﯽ ا ﺳﺖ ﮐﻪ ﺳﻄﻮح اﯾﻦ آدﯾﭙﻮﮐﺎﯾﻦ در ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪر وم ﻣﺘﺎﺑﻮﻟﯿﮏ ﮐﺎﻫﺶ ﻣﯽﯾﺎﺑﺪ. اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺎ ﻫﺪف ﺑﺮر ﺳﯽ ﺗﺄﺛ ﯿﺮ ﺗﻤﺮﯾﻦ ﻫﻮازي ﺑﺮ ﺳﻄﻮح آدﯾﭙﻮﻧﮑﺘﯿﻦ، CRP ﺳﺮﻣﯽ و ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧ ﺴ ﻮﻟﯿﻦ در زﻧﺎن داراي ﺳﻨﺪروم ﻣﺘﺎﺑﻮﻟﯿﮏ ﻃﺮح ﺷﺪه اﺳﺖ. 24 زن داراي ﺳﻨﺪروم ﻣﺘﺎﺑﻮﻟﯿﮏ (ﺳﻦ: 55/14±4/28 ﺳﺎل ، وزن: 93/44±9/29 ﮐﯿﻠﻮﮔﺮم، BMI: 32/65±1/51) ﺑﻪﻃﻮر ﺗ ﺼﺎدﻓﯽ ﺑﻪ دو ﮔﺮ وه ﺗﻤﺮﯾﻦ ﻫﻮازي (12 ﻧﻔﺮ) و ﮐﻨﺘﺮل (12 ﻧﻔﺮ) ﺗﻘ ﺴﯿﻢ ﺷﺪﻧﺪ. ﮔﺮ وه ﺗﻤﺮﯾﻦ ﻫﻮازي ﺑﻪ ﻣﺪت 10 ﻫﻔﺘﻪ و 3 ﺟﻠ ﺴﻪ در ﻫﺮ ﻫﻔﺘﻪ ﺑﺎ ﺷﺪت 60-70 در ﺻﺪ ﺣﺪاﮐﺜﺮ ﺿﺮﺑﺎن ﻗﻠﺐ ذﺧﯿﺮه ﺗﻤﺮﯾﻦ ﮐﺮدﻧﺪ . در ﺣﺎﻟﺖ ﭘﺎﯾﻪ و 48 ﺳﺎﻋﺖ ﭘﺲ از آﺧﺮ ﯾﻦ ﺟﻠﺴ ﮥ ﺗﻤﺮﯾﻨﯽ ﻧﻤﻮﻧﻪﻫﺎي ﺧﻮن ﺟﻤﻊآوري ﺷﺪ. از روش ELISA ﺑﺮاي اﻧﺪازهﮔﯿﺮي ﺳﻄﻮح ﻣﺘﻐﯿﺮﻫﺎي ﺳﺮﻣﯽ اﺳﺘﻔﺎده ﺷ ﯿﺪ. از آزﻣﻮنﻫﺎي t ﻣﺴﺘﻘﻞ و ﻫﻤﺒﺴﺘﻪ ﺑﺮاي ﺗﺤﻠﯿﻞ دادهﻫﺎ اﺳﺘﻔﺎده ﺷﺪ و ﺳﻄﺢ ﻣﻌﻨﺎداري 0/05 در ﻧﻈﺮ ﮔﺮﻓﺘﻪ ﺷﺪ. ﺗﺤﻠﯿﻞ دادهﻫﺎ ﻧﺸﺎن داد ﮐﻪ ﺗﻤﺮﯾﻦ ﻫﻮازي ﺑﻪ اﻓﺰاﯾﺶ ﻣﻌﻨﺎدار آدﯾﭙﻮﻧﮑﺘﯿﻦ و HDL و ﮐﺎﻫﺶ ﻣﻌﻨﺎدار CRP، ﮔﻠﻮﮐﺰ، ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧ ﺴﻮﻟﯿﻦ (0/05˂P)، وزن ﺑﺪن و دور ﮐﻤﺮ ﻣﻨﺠﺮ ﻣﯽ ﺷﻮد (0/05˂P). ﺑﺎ اﯾﻦ ﺣﺎل، ﺗﻐﯿﯿﺮات اﻧﺴﻮﻟﯿﻦ، ﺗﺮيﮔﻠﯿﺴﺮﯾﺪ و ﻣﺘﻮﺳﻂ ﻓﺸﺎر ﺧﻮن ﭘﺲ از10 ﻫﻔﺘﻪ ﺗﻤﺮﯾﻦ ﻫﻮازي ﻣﻌﻨﺎدار ﻧﺒﻮد (0/05>P). ﺗﻤﺮﯾﻦ ﻫﻮازي ﺑﺎ اﻓﺰاﯾﺶ ﺳﻄﻮح آدﯾﭙﻮﻧﮑﺘﯿﻦ ﺳﺮﻣﯽ و ﺑﻬﺒﻮد ﺑﺮﺧﯽ ﺷﺎﺧﺺ ﻫﺎي ﺳﻨﺪروم ﻣﺘﺎﺑﻮﻟﯿﮏ و و ﺿﻌﯿﺖ اﻟﺘﻬﺎﺑﯽ در زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪ روم ﻣﺘﺎﺑﻮﻟﯿﮏ ﻫﻤﺮاه اﺳــﺖ و ﺑﻪﻧﻈﺮ ﻣﯽرﺳــﺪ ﺗﻐﯿﯿﺮات آدﯾﭙﻮﻧﮑﺘﯿﻦ ﻣﯽﺗﻮاﻧﺪ ارﺗﺒﺎﻃﯽ ﺑﯿﻦ ﺑﺎﻓﺖ ﭼﺮﺑﯽ و ﺗﺄﺛﯿﺮات ﻣﻔﯿﺪ ﺗﻤﺮﯾﻨﺎت ﻫﻮازي در زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪروم ﻣﺘﺎﺑﻮﻟﯿﮏ ﺑﺎﺷﺪ.

Adiponectin is known as an adipokine with anti-inflammatory and anti- insulin resistance effects. The levels of this adipokine reduce in patients with metabolic syndrome. The aim of this study was to investigate the effect of aerobic exercise on serum levels of adiponectin and CRP and insulin resistance in women with metabolic syndrome. 24 women with metabolic syndrome (age: 55.14±4.28 yrs, weight: 93.44±9.29 kg and BMI: 32.65±1.51 kg/m2) were randomly divided into 2 groups: aerobic exercise (n=12) and control (n=12). Aerobic exercise subjects trained for 10 weeks, 3 sessions/week with an intensity of 60-70% of maximum heart rate reserve. Blood samples were collected at baseline and 48 hours after the last training session. ELISA was used to measure levels of serum variables and independent and dependent t tests were used for data analysis while the level of significance was considered P≤0.05. Data analysis showed that aerobic exercise significantly increased adiponectin and HDL, and significantly reduced CRP, glucose, insulin resistance, body weight, and waist circumference (P˂0.05). However, insulin, triglycerides and mean blood pressure changes were not significant after 10 weeks of aerobic exercise (P>0.05). Aerobic exercise is associated with an increase in serum adiponectin levels and the improvement of some metabolic syndrome markers and inflammatory states in women with metabolic syndrome and it seems that adiponectin changes can be a link between adipose tissue and the beneficial effects of aerobic exercise in women with metabolic syndrome.