تاثير مصرف سيليبوم ماريانوم همراه با يك دوره تمرينات فزاينده بر پاسخ اكسيداني به يك جلسه تمرين حاد در كشتي گيران جوان

The Effect of Silybummarianum Consumption along with a Period of Increasing Exercises on the Oxidative Response to an Acute Exercise Session in Young Wrestlers

ﻓﻌﺎﻟﯿﺖ ورزﺷﯽ ﺷﺪﯾﺪ ﻣﻮﺟﺐ ﺗﻮﻟﯿﺪ رادﯾﮑﺎل ﻫﺎي آزاد و آﺳﯿﺐ ﻫﺎي ﻧﺎﺷﯽ از اﺳﺘﺮس اﮐﺴﺎﯾﺸﯽ ﻣﯽ ﺷﻮد. در اﯾﻦ ارﺗﺒﺎط، ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﺑﺎ ﻫﺪف ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮ ﻣﺼﺮف ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم ﻫﻤﺮاه ﺑﺎ ﯾﮏ دوره ﺗﻤﺮﯾﻨﺎت ﻓﺰاﯾﻨﺪه ﺑﺮ ﭘﺎﺳﺦ اﮐﺴﯿﺪاﻧﯽ ﺑﻪ ﯾﮏ ﺟﻠﺴﻪ ﺗﻤﺮﯾﻦ ﺣﺎد در ﮐﺸﺘﯽ ﮔﯿﺮان ﺟﻮان اﻧﺠﺎم ﺷﺪ. روش ﺑﺮرﺳﯽ: 20 ﻧﻔﺮ از ﮐﺸﺘﯽ ﮔﯿﺮان ﺧﻮب ﺗﻤﺮﯾﻦ ﮐﺮده، ﭘﺲ از اﺧﺬ رﺿﺎﯾﺘﻨﺎﻣﻪ ﮐﺘﺒﯽ ﺑﻪ ﺻﻮرت ﺗﺼﺎدﻓﯽ ﺑﻪ دو ﮔﺮوه ﺗﻤﺮﯾﻦ ﺑﺎ ﻣﮑﻤﻞ ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم و ﺗﻤﺮﯾﻦ ﺑﺎ داروﻧﻤﺎ ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. ﮔﺮوه ﻣﮑﻤﻞ ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم ﺳﻪ ﺑﺎر در روز ﺑﺎ دوز 300 ﻣﯿﻠﯽ ﮔﺮم ﺑﻪ ﻣﺪت ﭼﻬﺎر ﻫﻔﺘﻪ ﻣﮑﻤﻞ دﻫﯽ ﺷﺪﻧﺪ. ﺧﻮنﮔﯿﺮي ﻗﺒﻞ و ﺑﻼﻓﺎﺻﻠﻪ ﺑﻌﺪ از ﯾﮏ ﺟﻠﺴﻪ ﺗﻤﺮﯾﻦ ﯾﮑﺴﺎن ﻗﺒﻞ از ﻣﮑﻤﻞدﻫﯽ و ﯾﮏ ﻣﺎه ﭘﺲ از آن اﻧﺠﺎم ﺷﺪ. ﺑﻪﻣﻨﻈﻮر ﺗﺠﺰﯾﻪ و ﺗﺤﻠﯿﻞ دادهﻫﺎ از آزﻣﻮن ﺗﺤﻠﯿﻞ وارﯾﺎﻧﺲ ﺑﺎ اﻧﺪازهﻫﺎي ﻣﮑﺮر و ﻧﯿﺰ از آزﻣﻮن t ﻣﺴﺘﻘﻞ اﺳﺘﻔﺎده ﮔﺮدﯾﺪ. ﯾﺎﻓﺘﻪ ﻫﺎ: از ﻧﻈﺮ ﺑﯿﻦ ﮔﺮوﻫﯽ، ﻣﻘﺎدﯾﺮ ﺳﻮﭘﺮاﮐﺴﯿﺪ دﯾﺴﻤﻮﺗﺎز ﻗﺒﻞ از ﺗﻤﺮﯾﻦ و ﭘﺲ از ﻣﮑﻤﻞ دﻫﯽ )0/032=P( و ﺑﻼﻓﺎﺻﻠﻪ ﭘﺲ از ﺗﻤﺮﯾﻦ و ﭘﺲ از ﻣﮑﻤﻞ دﻫﯽ )0/002=P( در ﮔﺮوه ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم اﻓﺰاﯾﺶ ﻣﻌﻨﺎداري داﺷﺖ. ﻫﻤﭽﻨﯿﻦ ﮐﺎﻫﺶ ﻣﻌﻨﺎداري در ﻣﻘﺎدﯾﺮ ﻣﺎﻟﻮن دي آﻟﺪﻫﯿﺪ ﻗﺒﻞ از ﺗﻤﺮﯾﻦ و ﭘﺲ از ﻣﮑﻤﻞ دﻫﯽ )001/ 0=P( و ﺑﻼﻓﺎﺻﻠﻪ ﺑﻌﺪ از ﺗﻤﺮﯾﻦ و ﭘﺲ از ﻣﮑﻤﻞدﻫﯽ )0/001=P( در ﮔﺮوه ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم وﺟﻮد داﺷﺖ. ﻋﻼوهﺑﺮاﯾﻦ، ﻣﻘﺎدﯾﺮ آﻧﺘﯽ اﮐﺴﯿﺪان ﺗﺎم ﻗﺒﻞ از ﺗﻤﺮﯾﻦ و ﭘﺲ از ﻣﮑﻤﻞدﻫﯽ )0/001=P( و ﺑﻼﻓﺎﺻﻠﻪ ﺑﻌﺪ از ﺗﻤﺮﯾﻦ و ﭘﺲ از ﻣﮑﻤﻞدﻫﯽ )0/008=P( در ﮔﺮوه ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم اﻓﺰاﯾﺶ ﻣﻌﻨﺎداري داﺷﺖ. ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ آزﻣﻮن ﺗﺤﻠﯿﻞ وارﯾﺎﻧﺲ ﺑﺎ اﻧﺪازه ﻫﺎي ﻣﮑﺮر، ﻣﯿﺎﻧﮕﯿﻦ ﻣﻘﺪار ﻣﺎﻟﻮن دي آﻟﺪﻫﯿﺪ در ﮔﺮوه ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم ﮐﻤﺘﺮ از ﮔﺮوه ﮐﻨﺘﺮل ﺑﻮد. ﻧﺘﯿﺠﻪ ﮔﯿﺮي: ﻣﯽ ﺗﻮان ﮔﻔﺖ ﻣﺼﺮف ﻣﮑﻤﻞ ﺳﯿﻠﯿﺒﻮم ﻣﺎرﯾﺎﻧﻮم در ورزش ﻫﺎي ﻓﺰاﯾﻨﺪه ﺳﺒﺐ ﮐﺎﻫﺶ ﺷﺎﺧﺺ ﻫﺎي اﮐﺴﯿﺪاﻧﺖ و اﻓﺰاﯾﺶ ﺷﺎﺧﺺ ﻫﺎي آﻧﺘﯽ اﮐﺴﯿﺪان ﻣﯽ ﺷﻮد.

Intense exercise results in the production of free radicals and damage caused by oxidative stress. In this regard, the present study aimed to investigate the effect of Silybummarianum consumption along with a period of increasing exercises on the oxidative response to an acute exercise session in young wrestlers. Methods: A total of 20 well-exercised wrestlers, were randomly divided into two groups of exercise along with Silybummarianum consumption and exercise along with placebo consumption after obtaining written consent. The Silybummarianum supplement group was supplemented at a dose of 300 mg, three times a day for four weeks. Blood samples were taken before and immediately after an equal training session before supplementation and after one month of supplementation. In order to analyze the data, repeated measures analysis of variance and independent t-test were used. Results: In terms of between group differences, there was a significant increase in superoxide dismutase levels before exercising and after supplementation (p = 0.032) and immediately after exercise and after supplementation (p = 0.002) in the Silybummarianum group. There was also a significant decrease in malondialdehyde levels before exercise and after supplementation (p = 0.001) and immediately after supplementation (p = 0.001) in the Silybummarianum group. Moreover, there was a significant increase in total antioxidant values before exercise after supplementation (p = 0.001) and immediately after exercise and after supplementation (p = 0.008) in the Silybummarianum group. According to the repeated measures ANOVA, the mean level of malondialdehyde in the Silybummarianum group was lower than the control group. Conclusion: Therefore, it can be concluded that the consumption of Silybummarianum in increasing exercises leads to the decrease of oxidant indexes and increase in antioxidant indexes.