The Effect of 8 Weeks Aerobic Training on Angiogenesis (VEGF) and Angiostatic (ES) Factors In Sedentary Women

Background Aims: It is more important to know which of physical activities could be the most effective way to cause angiogenesis. In this regards, we have investigated an 8week aerobic training on vascular endothelial growth factor (VEGF) and Endostatin (ES) in sedentary women. Materials Methods: 20 volunteer inactive women were chosen and were randomly divided in 2 groups of aerobic and control. Aerobic training programme consisted of 3 days per week for 8 weeks, each consists of 30 minutes with intensity of 6570% of maximum heart rate was performed.. Before and after training, we have tested aerobic training and control group after an overnight fast. Blood Samples were used to conduct Enzymelinked immunosorbent assay (ELISA). Independent and Dependent TTest t were performed to see the significance level of (P 0.05. Results: Statistical analysis revealed that aerobic training increased VEGF and decreased ES to a significant level. Consequently, the results of Independent T Test revealed that there is an obvious difference (P 0.05), between the amount of VEGF and ES in control and intervention group. Conclusion:The results show that the equilibrium between angiogenesis and angiostatic agents. As a result, aerobic training is shifted toward angiogenesis factors. This result helps us to understand the process of angiogenesis consistence with aerobic training activities.