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Serum Levels of Stress Oxidants in Depression

Introduction. Depression as a cause of stress increase free radicals in serum. It can oxidize lipids and result in atherosclerosis. Kinds of these products are malondialdhyde (MAD), conjugated diene (CD) and antioxidants capacity. Methods. Two groups of patients with major deppressive disorder (MDD) were studied. Group one consisted of filthy patients with unipolar MDD, second group was bipolar MDD and third one was control healthy ones. Diagnosis was confirmed by DSM-IV. Beck test was used to follow up patients. Before and after three month of treatment, MAD, CD and antioxidants capacity were compaired in three groups. Result s . MAD and antioxidant capacity were decreased after treatment in unipolar and bipolar MOD (P<0.001). But, there was no significant difference between CD serum levels before from after study. Discussion . Stress oxidants have a rcognized effect on coronary artery disease by lipid peroxidation. So, by findings in this study, it is believed that antideppressive therapy can reduce coronary artery events in patients suffered from deppressive disorders, by reducing these agents in serum.