مقايسه سديم والپروآت و پروپرانولول در پيشگيري از حملات ميگرن

Migraine Headache Management: Propranolol versus Sodium Valproate

Migraine is a paroxysmal disorder with attacks of headache, nausea, vomiting, photo- and phono phobia and malaise. Migraine treatment is a mystery of medicine yet. We compare the efficacy of sodium valproate versus propranolo! in our patients. Two 35 members groups with migraine headache (according to criteria of international headache society) were selected. At first, we discontinued any drugs used by subjects. In group one we started sodium valproate by dose 200 mg/day then increased it up to 600 mg/day during 3 weeks. In another group, propranolo was started 40 mg/day and was increased up to 80 mg/day in a period of 3 weeks. After 12 weeks of treatment, improvement of headache was compaired between groups. Headache severity, freqency and duration were similar in two groups after 12 weeks. It seems that propranolo and sodium valproate have the same affects on migraine headache.