مقايسه اثر پيشگيري كننده سايميتيدين و كيناكرين بر روي ايجاد زخم گوارشي ناشي از استرس و آسپرين در رات

Comparsion of Preventive Effect of Cimetidine and Quinacrine on Stress and Aspirin Induced Peptic Ulcer

Introduction. Cimetidine and quinacrine have protective effect on gastroduodenal lesions. In this study we compared efficacy of cimetidine and quinacrine for prevention of stress and aspirin Induced Peptic Ulcer. Methods. In an experimental studey, 36 rats randomly divided into 2 groups and each group divided into 3 subgroups of 6 rats. First subgroups of each group immersed in a water bath for 6 hours, or received ASA (250 mg/kg) orally with no prophylaxis (control groups). Second and third subgroups respectiely recieved quinacrine (30mg/kg) or cimetidine (20mg/kg) one hour before induction of gastric lesion by water immersion or ASA. Then the gastric mucosal lesions were assessed microscopically and marcroscopically. Results. Prophylaxis with cimetidine and quinacrine both, significantly were effective (p<0.05) but better prophylactic effect of quinacrine was not statistically significant (P>0.05). Discussion. In conclusion, quinacrine and cimetidine possess signifcant antiulcer and cytprotective activity against stress, and aspirin induced gastric lesions.