اثربخشي شناخت درماني مبتني بر ذهن آگاهي بر اينترلوكين-6 و سن تندرستي در زنان مبتلا به سرطان پستان

The effectiveness of mindfulness-based cognitive therapy on interleukin 6 (IL-6) and biological age in female breast cancer patients

زمينه و هدف: هدف از انجام تحقيق حاضر تبيين اثربخشي شناخت درماني مبتني بر ذهن آگاهي بر اينترلوكين -6 (IL-6) و سن تندرستي زنان مبتلا به سرطان پستان شهر تهران بود. روش­كار: تحقيق حاضر از نوع نيمه تجربي با طرح پيش‌ آزمون- پس‌آزمون و دو مرحله اندازه­گيري (سه ماه و شش ماه پس از اندازه­گيري اول) بود. بدين منظور از بين زنان مبتلا به سرطان پستان مراجعه كننده به مراكز درماني علوم پزشكي تهران و داراي شرايط مطالعه، تعداد 20 نفر داوطلب به طور تصادفي انتخاب و به دو گروه آزمايش (10 نفر) و گروه كنترل (10 نفر) تقسيم شدند. در ادامه گروه آزمايش هشت جلسه 5/1 ساعته در جلسات گروهي شناخت درماني مبتني بر ذهن آگاهي شركت كردند و گروه كنترل، برنامه درماني عادي خود را انجام دادند. داده‌هاي تحقيق با روش تحليل واريانس با اندازه‌ گيري مكرر تحليل شد. يافته‌ها: نتايج نشان داد كه برنامه درماني نتوانست تأثير معناداري بر اينترلوكين -6 (IL-6) داشته باشد (05/0

Background: The purpose of the present study was to determine the effectiveness of mindfulness-based cognitive therapy on interleukin-6 (IL-6) and the health status of women with breast cancer in Tehran. Methods: The present study was a quasi-experimental study with pre-test and posttest design and two measurement stages (three months and six months after the first measurement). For this purpose, among women with breast cancer referred to Tehran Medical Sciences Medical Centers and under study conditions, 20 volunteers were randomly selected and divided into experimental (n = 10) and control (n = 10) groups. The experimental group then participated in eight sessions of 1.5-hour sessions of mindfulness-based cognitive therapy sessions and the control group performed their usual treatment plan. The data were analyzed by repeated measure ANOVA. Results: The results of the data analysis showed that the treatment program was unable to have a significant effect on interleukin 6 (P>0.05) but was able to decrease biological age (P<0.01). The results of the two follow-up stages show that the intervention was able to maintain its effects throughout time. Conclusion: According to the research findings mindfulness based cognitive therapy is able to improve the biological age of breast cancer patients. But further research is needed on the effect of psychotherapy on biomarkers such as interleukin-6.