اثر مكمل ال آرژنين بر پروفايل ليپيدي بيماران مبتلا به ديابت نوع 2

The Effect of L-Arginin Supplementation on lipid profiles in patients with diabetes type 2

زمينه و هدف: رشد چشمگير آمار مبتلايان به ديابت مليتوس و خطر عوارض آن، لزوم تمركز بر يافتن راه­هاي جديد كنترل آن را مطرح مي­نمايد. مطالعه حاضر به منظور بررسي اثر مكمل ياري L-Arginine بر پروفايل ليپيدها در بيماران ديابت نوع2 انجام شد. مواد و روش‌ها: در يك كارآزمايي باليني تصادفي شده دوسوكور 75 بيمار مبتلا به ديابت نوع 2 به طور تصادفي به سه گروه تقسيم شدند. 1) 3‌گرم ال آرژنين در روز 2 6‌گرم ال آرژنين در روز و 3 گروه دارونما تقسيم شدند. قد، وزن، دور كمر،HDL ‌، TG، LDL و كلسترول تام قبل و بعد از 3 ماه مداخله اندازه گيري شد. نتايج: در گروه مداخله يك تغيير معناداري در هيچ يك از پيراسنج­هاي چربي ايجاد نشد (0.05

Background & Objective: The prominent growth in the statistics of the patients with Diabetes Mellitus (DM) and the danger of its complication states a necessity to focus on finding new ways to control it. The present study then was performed to survey the effect of L-Arginin supplementation on the metabolism of sugar and lipid profiles in patients with diabetes type 2. Materials & Methods: In a randomized double-blind clinical trial, 75 patients with diabetes type 2 were divided into three groupsrandomly: 1. 3 gr L-Arginin per day, 2. 6 gr L-Arginin per day and 3. The placebo group. Height, weight, waist, High Density Lipoprotein (HDL), Triglycerides (TG), Low Density ipoprotein (LDL), and the total cholesterol were measured before and after three months of intervention. Results: no significant change was made in any of the lipid parameters in the intervention group. However, the two means of cholesterol and LDL decreased from169.12±34.83 mg/dl to 142.08±32.13mg/dl(P-Value<0.001) and from 96.80±35.46mg/dl to 86.64±32.65(P-Value=0.001), respectively though The changes in TG and HDL were not significant. Conclusion: Daily consumption of six gram L-Arginin during three months improves the lipid profiles in patients with Diabetes type2. Nevertheless, the dosage of three gram in a day of this supplement has no effect on the blood lipids status.