Ultrasound-assisted emulsification solidified floating organic drop microextraction-GFAAS for determination of ultratrace aluminum: Response surface methodology and Box-Behnken Design

A simple, inexpensive and easytouse method of ultrasoundassisted emulsification of solidified floating organic drops microextraction (UAESFODME) coupled to GFAAS was developed for the extraction and preconcentration of aluminum. The factors affect the UAESFODME of aluminum, using alizarin red S (ARS) as complexing agent, were determined using onefactorata time and further optimization was carried out by BoxBehnken design and response surface methodology (RSM). Under the optimized conditions: extraction solvent 180 µL, pH 4.07, volume of dispersive solvent 60.0 µL, ARS 2.0 mg, and sample volume of 25 mL, an enrichment factor of 80, a detection limit of 0.16 µg L−1 and a relative standard deviation of 3.55.0 % were obtained. The method was effectively applied for analyzing different water samples and milk powder.