ﺗﺐ و ﺳﺮﻓﻪ دو ﻋﺎﻣﻞ ﻣﻬﻢ در ﺷﻨﺎﺳﺎﯾﯽ ﺑﯿﻤﺎران ﻣﺒﺘﻠﺎ ﮐﻮوﯾﺪ-19: ﻣﺘﺎآﻧﺎﻟﯿﺰ

Fever and Cough are Two Important Factors in Identifying Patients with the Covid-19: A Meta-Analysis

زﻣﯿﻨﻪ و ﻫﺪف: از ﻣﻬﻤﺘﺮﯾﻦ ﻋﻠﺎﺋﻢ ﺑﺎﻟﯿﻨﯽ در ﺑﯿﻤﺎران ﻣﺒﺘﻠﺎ ﺑﻪ ﮐﻮوﯾﺪ-19 ﺗﺐ و ﺳﺮﻓﻪ ﻣﯽﺑﺎﺷﺪ ﮐﻪ اﻃﻠﺎع از ﻣﯿﺰان ﺷﯿﻮع اﯾﻦ ﻋﻠﺎﺋﻢ ﺟﻬﺖ ﺷﻨﺎﺳﺎﯾﯽ و ﻏﺮﺑﺎﻟﮕﺮي اوﻟﯿﻪ ﺑﯿﻤﺎران از اﻫﻤﯿﺖ وﯾﮋهاي ﺑﺮﺧﻮردار اﺳﺖ. ﻧﺘﺎﯾﺞ ﻣﻄﺎﻟﻌﺎت اﻧﺠﺎم ﺷﺪه ﻣﻘﺎدﯾﺮ ﻣﺘﻔﺎوﺗﯽ از ﺷﯿﻮع اﯾﻦ دو ﻋﻠﺎﻣﺖ در ﻣﺒﺘﻠﺎﯾﺎن را ﻧﻤﺎﯾﺶ ﻣﯽدﻫﺪ، ﻟﺬا ﻫﺪف ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﯾﮑﺴﺎن ﺳﺎزي آﻣﺎر ﺷﯿﻮع ﺗﺐ و ﺳﺮﻓﻪ در ﻣﺒﺘﻠﺎﯾﺎن اﯾﻦ وﯾﺮوس ﻣﯽﺑﺎﺷﺪ. روشﻫﺎ: در اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﻣﺘﺎآﻧﺎﻟﯿﺰ ﺑﺎ اﺳﺘﻔﺎده از دﺳﺘﻮراﻟﻌﻤﻞ PRISMA ﺟﺴﺘﺠﻮ در ﭘﺎﯾﮕﺎهﻫﺎي اﻃﻠﺎﻋﺎﺗﯽ ﺑﯿﻦاﻟﻤﻠﻠﯽ Embase،PubMed ،Scopus ،ScienceDirect و ISI) Web of Science( در ﻓﺎﺻﻠﻪ اﮐﺘﺒﺮ 2019 ﺗﺎ ﻣﺎرس 2020 ﺑﺎ ﮐﻠﯿﺪواژهﻫﺎي ﻟﺎﺗﯿﻦ Prevalence، Fever ،SARS-CoV-2 ،COVID-19 ،2019-nCoV و Cough اﻧﺠﺎم ﮔﺮﻓﺖ. ﺟﻬﺖ اﻧﺠﺎم ﺗﺤﻠﯿﻞ، از ﻣﺪل اﺛﺮات ﺗﺼﺎدﻓﯽ اﺳﺘﻔﺎده و ﻧﺎﻫﻤﮕﻨﯽ ﻣﻄﺎﻟﻌﺎت ﺑﺎ ﺷﺎﺧﺺ I2 ﺑﺮرﺳﯽ ﺷﺪ. آﻧﺎﻟﯿﺰ دادهﻫﺎ ﺑﺎ ﻧﺮماﻓﺰار )2 Comprehensive Meta-Analysis (Version اﻧﺠﺎم ﮔﺮﻓﺖ. ﯾﺎﻓﺘﻪﻫﺎ: در ﺑﺮرﺳﯽ ﻧﺘﺎﯾﺞ ﺣﺎﺻﻞ 13 ﻣﻘﺎﻟﻪ و ﺑﺮرﺳﯽ 2131 ﻧﻔﺮ، ﺷﯿﻮع ﮐﻠﯽ ﺗﺐ در ﺑﯿﻤﺎران ﻣﺒﺘﻠﺎ ﺑﻪ ﮐﻮوﯾﺪ-19 در ﺑﺪو ورود ﺑﻪ ﺑﯿﻤﺎرﺳﺘﺎن، 78/2 درﺻﺪ )65/4-87/2 درﺻﺪ: ﺣﺪود اﻃﻤﯿﻨﺎن 95%( و ﺷﯿﻮع ﮐﻠﯽ ﺳﺮﻓﻪ در اﯾﻦ ﺑﯿﻤﺎران، 54/9 درﺻﺪ )45/1-64/3 درﺻﺪ: ﺣﺪود اﻃﻤﯿﻨﺎن 95%( ﺑﻪ دﺳﺖ آﻣﺪ. ﺑﻪﻣﻨﻈﻮر ﺑﺮرﺳﯽ اﺛﺮات ﻋﻮاﻣﻞ ﺑﺎﻟﻘﻮه ﻣﺆﺛﺮ در ﻧﺎﻫﻤﮕﻮﻧﯽ ﺷﯿﻮع ﮐﻠﯽ ﺗﺐ و ﺳﺮﻓﻪ در ﺑﯿﻤﺎران ﻣﺒﺘﻠﺎ ﺑﻪ ﮐﻮوﯾﺪ-19، از ﻣﺘﺎرﮔﺮﺳﯿﻮن در ﻣﻮرد ﺳﻦ ﻣﺒﺘﻠﺎﯾﺎن اﺳﺘﻔﺎده ﺷﺪ و ﻣﺸﺎﻫﺪه ﺷﺪ ﮐﻪ ﺑﺎ اﻓﺰاﯾﺶ ﺳﻦ ﺑﯿﻤﺎران ﺗﺐ و ﺳﺮﻓﻪ اﻓﺰاﯾﺶ ﻣﯽﯾﺎﺑﺪ و اﯾﻦ اﺧﺘﻠﺎف از ﻧﻈﺮ آﻣﺎري ﻣﻌﻨﺎدار ﺑﻮد )05.P<0(. ﻧﺘﯿﺠﻪﮔﯿﺮي: ﻧﺘﺎﯾﺞ اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﻧﺸﺎن ﻣﯽدﻫﺪ ﮐﻪ ﺷﯿﻮع ﺗﺐ و ﺳﺮﻓﻪ ﺑﻪ ﻋﻨﻮان دو ﻋﺎﻣﻞ ﻣﻬﻢ در ﺷﻨﺎﺳﺎﯾﯽ ﺑﯿﻤﺎران ﻣﺒﺘﻠﺎ ﺑﻪ ﮐﻮوﯾﺪ-19ﺑﺎﻟﺎ ﻣﯽﺑﺎﺷﺪ. از اﯾﻦ رو، ﺑﺮاي ﺑﻬﺒﻮد وﺿﻌﯿﺖ ﯾﺎد ﺷﺪه و ﻋﻠﺖﯾﺎﺑﯽ و ﻧﻈﺎرت در ﺗﻤﺎم ﺳﻄﻮح، ﺑﺎ اراﺋﻪ ﺑﺎزﺧﻮرد ﺑﻪ ﺑﯿﻤﺎرﺳﺘﺎنﻫﺎ ﺑﺎﯾﺪ راﻫﮑﺎرﻫﺎي ﻣﻨﺎﺳﺐ اﻋﻤﺎل ﮔﺮدد.

Background and Aim: The most important clinical symptoms in patients with COVID-19 on admission at the hospital are fever and cough. The results of the studies show different levels of prevalence of these two symptoms in patients. The aim of this study was to coordinate the prevalence of fever and cough in patients with COVID-19. Methods: In this meta-analysis study, searching was performed on international databases of Embase, ScienceDirect, Scopus, PubMed and Web of Science (ISI) between October 2019 to March 2020 with keywords, 2019-nCoV, COVID-19, SARS-CoV-2, Fever and Cough. Random effects model was used for analysis and heterogeneity of studies with I2 index was investigated. Data were analyzed using Comprehensive Meta-Analysis (Version 2). Results: In a meta-analysis of 13 articles and 2131 cases, the overall prevalence of fever in patients with COVID-19 on admission at the hospital was 78.2% (95% CI: 65.4-87.2%) and the overall prevalence of cough in these patients was 54.9% (95% CI: 45.1-64.3%). The meta-regression showed that fever and cough increased with age and this difference was statistically significant (P <0.05). Conclusion: The results of this study indicate that the prevalence of fever and cough is high in identifying patients with COVID-19. Therefore, appropriate solutions should be put in place to improve the aforementioned situation, and to provide feedback to hospitals at all levels.