بررسي اثر ميدازولام بر ميزان اشباع اكسيژن خوني شرياني در آندسكوپي دستگاه گوارش دستگاه گوارش فوقاني

Effects of midazolam on arterial oxygen saturation during upper gastrointestinal endoscopy

Background: Anxiety is a common problem during GI endoscopy. Fearing has different effects on endoscopy procedure and midazolam has been revealed to be an effective agent to reduce this fear. Thus. the present study was conducted to determine the effects of midazolam on arterial oxygen saturation during upper gastrointestinal endoscopy in Booali hospital in 2001. Materials and methods: 60 patients had entered this double-blinded sequential clinical trial. Patients had no previous history of cardiopulmonary, liver or kidney disease and were nonsmoker. They have been randomly distributed in either the case or control group. One minute before the endoscopy the case group was received 0.07mg/kg midazolam intravenously and the control group was given 5cc normal saline intravenously. Arterial oxygen saturation was determined one minute before the endoscopy till one minute following the procedure, each a minute. Results: Groups were matched according to the sex, age. duration of endoscopy, and one-minute preoperative Sao:. Sao2 before the procedure was 95.7±1.48 and 95.9±1.47 per cent in the control and case group. respectively. Following the endoscopy it was changed to 95.511.5 and 95.6±1.58 per cent in the control and case group, respectively. The difference was not statistically significant. Conclusion: Midazolam does not reduce arterial oxygen saturation, though, monitoring the susceptible patients during the procedure is highly recommended.