ارزش اخباري اندازه دور كمر براي پيشگويي عوامل خطرساز بيماريهاي قلبي - عروقي در افراد داراي اضافه وزن يافته هايي از مطالعه قند و ليپيد تهران

Evaluation of waist circumference to predict cardiovascular risk factors in overweight Tehranian population: findings from Tehran Lipid and Glucose Study (TLGS)

Background: Waist circumference (WC) cut-points were derived by identifying WC values corresponding to BMi cutoffs for overweight and obesity and not on the basis of their relation to risk factors. This study was conducted to evaluate the WC cutoff points to predict CVD risk factors in overweight Tehranian population. Materials and methods: From the 15005 participants of TLGS, 10837 subjects were aged 18-74 years. Subjects taking medications affecting serum lipoproteins, blood pressure or carbohydrate methobolism were excluded from the study and finally, 3065 subjects (1406 males and 1659 females) with BMI= 25-29.9 were enrolled in this study. Weight, height and WC were measured and BMI was calculated. Blood pressure was evaluated using standard methods. Biochemical analyses were conducted on a fasting serum sample. Abdominal obesity was defined as WC> 102crn for men and ?_88cm for women. Hypertension and lipid disorders were defined based on JNC VI and ATP IT, respectively. Diabetes was considered as FBS>_ 126 mg/dl. Results: prevalent categories of risk factors in both genders. WC>102cm for men had very low sensitivity to detect cardiovascular risk factors. The specificity of this cut-point was relatively high. WC> 88cm had low sensitivity for identifying cardiovascular risk factors in women aged 18-34 years. Sensitivity tended to increase with age and specificity tended to decrease with age in both genders. These cut-off points had the highest positive predictive value for more prevalent risk factors in both genders. The negative predictive value was different for various risk factors among age groups. Conclusion: These cut-points failed to provide adequate evidence for the use of WC in detecting CVD risk factors. Further studies should be conducted to determine optimal WC cut-points for Iranians.