بررسي اثرات قلبي - عروقي قرص سرماخوردگي بزرگسالان و آنتي هيستامين دكونژستان در بيماران مبتلا به پرفشار خون

Cardiovascular effects of Adult Cold and Antihistamine Decongestant tablets in hypertensive patients

Background: This study is an attempt to evaluate the cardiovascular effects of Adult Cold and Antihistamine Decongestant tablets, both of which containing sympathomimctic agents, through comparing them with each other and also with placebo. Materials and methods: Thirty hypertensive patients with the mean age of 57.1±5.7 years received single oral dose of Adult Cold and Antihistamine Decongestant tablets or placebo, in a single blind. crossover trial with a wash out period of two weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were measured before and 10. 20. 30, 60, 120, and 240 minutes after administration of drugs and placebo. Results: With Antihistamine Decongestant tablets, significant increases in SBP (at minute-30, -60, -120. and -240), DBP (at minute-3() and -120), and MAP (at minute-30 and -60) were obtained in comparison to placebo following the drug administration. Heart rate was significantly decreased 60 minutes after Antihistamine Decongestant administration. With Adult Cold tablets, no significant change was observed in SBP, DBP, and MAP in comparison to placebo. The heart rate, however. showed a significant decrease 120 minutes after the drug administration. Conclusion: Sex has no effect on the aforementioned parameters. The results are considered as an alarm for the medical society as well as hypertensive patients regarding certain drugs which for long have been consumed as safe OTC drugs. For common cold, an effective drug such as Adult Cold can be recommended, which has no considerable effects on blood pressure.