عنوان مقاله :
The role of lecithin on topical anti-inflammatory activity of turmeric (Curcuma longa L.) ointment
پديد آورندگان :
Esmaeili ، Somayeh Shahid Beheshti University of Medical Sciences - Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine - Department of Traditional Pharmacy , Omid-Malayeri ، Saleh Islamic Azad University Pharmaceutical Sciences Branch , Hajimehdipoor ، Homa Shahid Beheshti University of Medical Sciences - Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine - Department of Traditional Pharmacy , Rasekh ، HamidReza Shahid Beheshti University of Medical Sciences - School of Pharmacy - Department of Pharmacoeconomy Administrative Pharmacy , Moghimi ، Hamid Reza Shahid Beheshti University of Medical Sciences - School of Pharmacy - Department of Pharmaceutics , Omid-Malayeri ، Soheil Shahed University - School of Medicine - Student Research Committee , Yaraee ، Roya Shahed University - School of Medicine - Department of Immunology , Jalali Nadoushan ، Mohammad Reza Shahed University - School of Medicine - Department of pathology and Anatomy
كليدواژه :
Turmeric , Inflammation , Iranian folk medicine , Rat , Curcuma longa ,
چكيده فارسي :
Background: Turmeric (Curcuma longa L.) is widely used in traditional medicine. In Iranian folk medicine, turmeric and egg yolk mixture is used for inflammation due to dislocations and strains. Since lecithin (one of the component of egg yolk) is an absorption enhancer, it seems this phospholipid can increase turmeric absorption and its antiinflammatory effect. Objective: In order to find the role of lecithin in the folklore formulation, antiinflammatory effects of ointments containing turmeric extract and lecithin have been studied. Methods: Ointment base was prepared using bees wax, vaseline, liquid paraffin and eucerin. Then, hydroalcoholic turmeric extract (2.5 % and 5 %) with lecithin (5 % and 15 %) or without lecithin were added to the ointment base. Antiinflammatory effect of the ointments was assessed in arthritis model in rat using complete Freund rsquo;s adjuvant. Ointments were used daily on the inflamed joints for 20 days. Finally, arthritis index, TNF alpha; concentration and histopathological changes of joints were determined. Results: The results showed that arthritis index has decreased in all groups but it was significant in groups of turmeric 2.5 % and turmeric 5 % with lecithin 15 %. TNF alpha; was decreased in all samples but reduction was more significant in group turmeric 2.5 %. Histopathological changes were significantly less in turmeric groups compared to ointment base group. Conclusion: It seems that local healers use egg yolk as a binder in formulation. In other words, turmeric 2.5 % ointment is preferable compared to other formulations.
عنوان نشريه :
گياهان دارويي
عنوان نشريه :
گياهان دارويي
