اﺛﺮ ﺗﻤﺮﯾﻨﺎت ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ ﺑﺮﺳﻄﺢ ﺳﺮﻣﯽ ﭘﺮوﮔﺮاﻧﻮﻟﯿﻦ و ﺷﺎﺧﺺ ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ در زﻧﺎن ﮐﻢ ﺗﺤﺮك داراي اﺿﺎﻓﻪ وزن و ﭼﺎق

Effect of High Intensity Interval Training on Serum Levels of Progranulin and Insulin Resistance Index in Young Sedentary Overweight and Obese Women

ﺳﺎﺑﻘﻪ و ﻫﺪف: ﭘﺮوﮔﺮاﻧﻮﻟﯿﻦ، آدﯾﭙﻮﮐﺎﯾﻦ ﻧﻮﻇﻬﻮر ﻣﺘﺮﺷﺤﻪ از ﺑﺎﻓﺖ ﭼﺮﺑﯽ اﺳﺖ ﮐﻪ ﺑﺎ ﺑﯿﻤﺎريﻫﺎي ﻣﺘﺎﺑﻮﻟﯿﮑﯽ ﻫﻤﺮاه ﺑﺎ ﭼﺎﻗﯽ ﻧﻈﯿﺮ ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ و دﯾﺎﺑﺖ ﻧﻮع دو ارﺗﺒﺎط دارد. ﻫﺪف از ﭘﮋوﻫﺶ ﺣﺎﺿﺮ ﺑﺮرﺳﯽ اﺛﺮ ﺗﻤﺮﯾﻦ ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ ﺑﺮ ﺳﻄﺢ ﺳﺮﻣﯽ ﭘﺮوﮔﺮاﻧﻮﻟﯿﻦ، اﻧﺴﻮﻟﯿﻦ، ﮔﻠﻮﮐﺰ ﻧﺎﺷﺘﺎ و ﺷﺎﺧﺺ ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ )HOMA-IR( در زﻧﺎن ﺟﻮان ﮐﻢﺗﺤﺮك ﭼﺎق و داراي اﺿﺎﻓﻪوزن ﺑﻮد. ﻣﻮاد و روﺷﻬﺎ: 20 زن داري اﺿﺎﻓﻪوزن و ﭼﺎق ﺑﻪﻃﻮر ﺗﺼﺎدﻓﯽ ﺑﻪ دو ﮔﺮوه ﺗﺠﺮﺑﯽ )ﻣﯿﺎﻧﮕﯿﻦ ﺳﻨﯽ 32/5±4/14 ﺳﺎل و ﺷﺎﺧﺺ ﺗﻮده ﺑﺪﻧﯽ 33/18±6/12 ﮐﯿﻠﻮﮔﺮم ﺑﺮ ﻣﺘﺮﻣﺮﺑﻊ( و ﮐﻨﺘﺮل )ﻣﯿﺎﻧﮕﯿﻦ ﺳﻨﯽ 35/45±2/33 ﺳﺎل و ﺷﺎﺧﺺ ﺗﻮده ﺑﺪﻧﯽ 26/58±1/65ﮐﯿﻠﻮﮔﺮم ﺑﺮ ﻣﺘﺮﻣﺮﺑﻊ( ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. آزﻣﻮدﻧﯽﻫﺎ در ﮔﺮوه ﺗﺠﺮﺑﯽ در ﻫﺸﺖ ﻫﻔﺘﻪ ﺗﻤﺮﯾﻦ ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ )ﯾﮏ دﻗﯿﻘﻪ ﺗﻨﺎوب دوﯾﺪن ﺑﺎ ﺷﺪت 90 درﺻﺪ ﺿﺮﺑﺎن ﻗﻠﺐ ﺑﯿﺸﯿﻨﻪ ﺑﺎ ﯾﮏ دﻗﯿﻘﻪ ﺗﻨﺎوب اﺳﺘﺮاﺣﺖ دوﯾﺪن ﺑﺎ ﺷﺪت 50-60 درﺻﺪ ﺿﺮﺑﺎن ﻗﻠﺐ ﺑﯿﺸﯿﻨﻪ، 10 ﻧﻮﺑﺖ در ﻫﺮ ﺟﻠﺴﻪ، 20 دﻗﯿﻘﻪ در ﻫﺮ ﺟﻠﺴﻪ، ﺳﻪ ﺑﺎر ﻫﻔﺘﻪ( ﺷﺮﮐﺖ ﮐﺮدﻧﺪ. اﻧﺪازهﮔﯿﺮي ﺷﺎﺧﺺﻫﺎي ﺧﻮﻧﯽ و آﻧﺘﺮوﭘﻮﻣﺘﺮي ﻣﻮرد ﺑﺮرﺳﯽ ﻗﺒﻞ و ﺑﻌﺪ از اﺟﺮاي ﭘﺮوﺗﮑﻞ ﺗﻤﺮﯾﻨﯽ اﻧﺠﺎم ﮔﺮﻓﺖ. ﺗﺠﺰﯾﻪ وﺗﺤﻠﯿﻞ دادهﻫﺎ ﺑﻪ ﮐﻤﮏ آزﻣﻮن ﺗﺤﻠﯿﻞ ﮐﻮوارﯾﺎﻧﺲ، ﺗﯽ زوﺟﯽ و آزﻣﻮن ﻫﻤﺒﺴﺘﮕﯽ ﭘﯿﺮﺳﻮن در ﺳﻄﺢ ﻣﻌﻨﺎداري آﻣﺎري 0/05

Background Purpose: Progranulin is a novel adipose tissue secreted adipokine correlating with obesity related metabolic diseases such as insulin resistance and type II diabetes. Purpose of this study was to investigate effect of high intensity interval training (HIIT) on serum levels of Progranulin, insulin and fasting glucose and insulin resistance index (HOMA-IR) in young sedentary overweight and obese women. Methodology: Twenty overweight and obese women randomly divided into two groups of experimental (mean age 32.5±4.14 years, body mass index 33.18±6.12 Kg/m2) and control (mean age 35.45±2.33 years, body mass index 26.58±1.65 Kg/m2). Subjects in experimental group participated in 8 weeks of HIIT (one minute of running interval at intensity of 90 percent of maximal heart rate and 1 minutes of rest interval of running at intensity of 50-60 percent of maximal heart rate). Blood factors and anthropometric indices were assessed before and after training protocol. Statistical analysis was done by Covariance, t-test and Pearson correlation at significant level of p < 0.05. Results: HIIT resulted in significant decreases in serum levels of Progranulin (P=.0.013), weight (P=.0.001), body mass index (P=.0.001) and body fat percent (P=.0.001). Moreover, there were significant difference between groups of experimental and control for insulin (P=.0.039), weight (P=.0.001), body mass index (P=.0.005) and body fat percent (P=.0.001). Conclusion: High intensity interval training (HIIT) resulted in significant decreases in serum levels of Progranulin and can be the effective procedure to improve body composition and metabolic status in young sedentary overweight and obese women.