ﭘﺎﺳﺦ ﺑﺮﺧﯽ ﻫﭙﺎﺗﻮﮐﯿﻦ ﻫﺎ و ﻣﻘﺎوﻣﺖ اﻧﺴﻮﻟﯿﻨﯽ ﺑﻪ ﯾﮏ دوره ﺗﻤﺮﯾﻨﺎت اﯾﻨﺘﺮوال ﺷﺪﯾﺪ در زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﮐﺒﺪ ﭼﺮب ﻏﯿﺮ اﻟﮑﻠﯽ

The Response of Some Hepatokines and Insulin Resistance to High Intensity Interval Training In Women with Non-Alcoholic Fatty Liver

ﺳﺎﺑﻘﻪ و ﻫﺪف: ﻫﭙﺎﺗﻮﮐﯿﻦﻫﺎي ﮐﺒﺪي ﯾﮑﯽ از ﻋﻮاﻣﻞ دﺧﺎﻟﺖ ﮐﻨﻨﺪه در ﺑﯿﻤﺎري ﮐﺒﺪ ﭼﺮب ﻏﯿﺮ اﻟﮑﻠﯽ ﻣﯽﺑﺎﺷﺪ. ﯾﮑﯽ از روشﻫﺎي درﻣﺎﻧﯽ ﻣﻮﺛﺮ در اﯾﻦ ﺑﯿﻤﺎري، ﺗﻤﺮﯾﻨﺎت ورزﺷﯽ ﻣﯽﺑﺎﺷﺪ. ﻫﺪف از ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﺑﺮرﺳﯽ ﭘﺎﺳﺦ ﺑﺮﺧﯽ ﻋﻮاﻣﻞ ﻫﭙﺎﺗﻮﮐﯿﻨﯽ ﺑﻪ ﯾﮏ دوره ﺗﻤﺮﯾﻨﺎت ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ در زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﮐﺒﺪ ﭼﺮب ﻏﯿﺮاﻟﮑﻠﯽ ﻣﯽﺑﺎﺷﺪ. ﻣﻮاد و روﺷﻬﺎ: ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ از ﻧﻮع ﻧﯿﻤﻪ ﺗﺠﺮﺑﯽ ﺑﻮده ﮐﻪ ﺟﺎﻣﻌﻪ ﻣﻮرد ﻣﻄﺎﻟﻌﻪ آن زﻧﺎن ﻣﺒﺘﻼ ﺑﻪ ﮐﺒﺪ ﭼﺮب ﻏﯿﺮ اﻟﮑﻠﯽ ﺑﻮد ﮐﻪ 25 ﻧﻔﺮ از آنﻫﺎ ﺑﻪ روش ﻧﻤﻮﻧﻪ ﮔﯿﺮي ﺗﺼﺎدﻓﯽ در دو ﮔﺮوه، ﺗﻤﺮﯾﻦ ﯾﺎ ﮐﻨﺘﺮل ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. ﭘﺮوﺗﮑﻞ ﺗﻤﺮﯾﻦ ﺗﻨﺎوﺑﯽ ﺷﺪﯾﺪ ﺑﻪ ﻣﺪت 8 ﻫﻔﺘﻪ و ﭼﻬﺎر ﺟﻠﺴﻪ در ﻫﻔﺘﻪ و ﻫﺮ ﺟﻠﺴﻪ ﺑﻪ ﻣﺪت 60 دﻗﯿﻘﻪ اﺟﺮا ﺷﺪ. ﻧﻤﻮﻧﻪﻫﺎي ﺧﻮﻧﯽ در ﺷﺮاﯾﻂ ﭘﯿﺶ و ﭘﺲ آزﻣﻮن ﺑﻪ ﻣﻘﺪار 5 ﺳﯽ ﺳﯽ از ورﯾﺪ ﺑﺎزوﯾﯽ ﮔﺮﻓﺘﻪ ﺷﺪ. ﻣﻘﺎدﯾﺮ ﮐﻤﻮﺗﺎﮐﺴﯿﻦ 2 ﺣﺎﺻﻞ از ﻟﮑﻮﺳﯿﺖ )LECT2(، ﻓﺎﮐﺘﻮر رﺷﺪ واﺑﺴﺘﻪ ﺑﻪ آﻧﮋﯾﻮﭘﻮﺋﯿﺘﯿﻦ )AGF( ، ﮔﻠﻮﺑﻮﻟﯿﻦ ﻣﺘﺼﻞ ﺑﻪ ﻫﻮرﻣﻮن ﺟﻨﺴﯽ )SHBG( و اﻧﺴﻮﻟﯿﻦ اﻧﺪازه ﮔﯿﺮي ﺷﺪ. ﺑﺮاي ﺑﺮرﺳﯽ ﺗﻐﯿﯿﺮات درون ﮔﺮوﻫﯽ ﭘﯿﺶآزﻣﻮن ﺑﺎ ﭘﺲآزﻣﻮن ﻣﺘﻐﯿﺮﻫﺎي واﺑﺴﺘﻪ از آزﻣﻮن ﺗﯽ واﺑﺴﺘﻪ، ﺑﺮاي ﺗﻌﯿﯿﻦ ﺗﻔﺎوت ﻣﻌﻨﺎدار ﺑﯿﻦ ﮔﺮوهﻫﺎ از آزﻣﻮن ﺗﯽ ﻣﺴﺘﻘﻞ اﺳﺘﻔﺎده ﺷﺪ. ﯾﺎﻓﺘﻪﻫﺎ: ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﻧﺸﺎن داد ﮐﻪ ﺑﻌﺪ از ﻫﺸﺖ ﻫﻔﺘﻪ ﺗﻤﺮﯾﻨﺎت اﯾﻨﺘﺮوال ﺷﺪﯾﺪ LECT2 و AGF در ﮔﺮوه ﺗﻤﺮﯾﻦ ﻧﺴﺒﺖ ﺑﻪ ﮔﺮوه ﮐﻨﺘﺮل و ﭘﯿﺶ آزﻣﻮن ﮐﺎﻫﺶ ﻣﻌﻨﺎدار و SHBG اﻓﺰاﯾﺶ ﻣﻌﻨﺎداري داﺷﺖ )0/05

Background and Purpose: Liver hepatokines are one of the contributing factors in non-alcoholic fatty liver disease. One of the most effective treatments for this condition is exercise. Therefore, the aim of this study was to investigate the response of some liver hepatokines to a period of high intensity interval training in women with fatty liver. Methodology: twenty Five women with non-alcoholic fatty liverwere randomly divided into two groups: exercise or control. The high intensity interval training protocol was performed for 8 weeks and four sessions per week for 60 minutes each session. Blood samples were taken from the arm vein to 5 cc pre- and post-test conditions. Plasma levels of Leukocyte-derived chemotaxin 2 (LECT2), angiopoietin-dependent growth factor (AGF), sex hormone-binding globulin (SHBG), and insulin were measured. Independent paired T-test was used to determine the intra-group changes of pre-test with post-test of dependent variables, and independent t-test was used to determine the significant difference between the groups. Results: The present study showed that after eight weeks of intense interval training LECT2 and AGF in the training group compared to the control had a significant decrease and SHBG significantly increased (p <0.05). Also, insulin resistance, body fat percentage, body mass index and waist to pelvic hip ratio have been significantly reduced in the exercise group compared to the control group (p <0.05). Conclusion: High intensity interval training in women seems to be a non-pharmacological solution to improve insulin resistance and improve fatty liver-related hepatokines.