مقايسه و بررسي تغييرات ژنومي SARS‑CoV‑2 در مقايسه با توالي كويد 19 در ايران

Investigation of SARS-CoV-2 Genomic Changes in Comparison with COVID-19 Sequence in Iran

ﯾﺮوس ﮐﺮوﻧﺎ )19-COVID( ﯾﮏ وﯾﺮوس RNA دار، ﺗﮏ رﺷﺘﻪ اي ﺑﺎ ﺳﻨﺲ ﻣﺜﺒﺖ اﺳﺖ. اﯾﻦ وﯾﺮوس ﻫﻢ ﺑﻄﻮر ﻃﺒﯿﻌﯽ ﻫﻢ ﺑﻌﺪ از اﻧﺘﻘﺎل ﺑﻪ اﻓﺮاد دﭼﺎر ﺟﻬﺶ ﻣﯽ ﺷﻮد، ﮐﻪ اﻧﺘﻘﺎل آن از ﺑﯿﻤﺎران ﺑﻪ ﺳﺎﯾﺮ اﻓﺮاد ﻣﻮﺟﺐ اﻓﺰاﯾﺶ ﺟﻬﺶ در ژﻧﻮم آن ﺷﺪه اﺳﺖ. ﺟﻬﺶ در اﯾﻦ وﯾﺮوس ﺑﻪ ﺳﺎزﮔﺎري آن ﺑﺎ ﺷﺮاﯾﻂ ﻣﺨﺘﻠﻒ ﮐﻤﮏ ﮐﺮده و ﻗﺪرت ﺑﯿﻤﺎري زاﯾﯽ در اﻓﺮاد ﺟﺪﯾﺪ را اﻓﺰاﯾﺶ داده اﺳﺖ. ﺑﺮرﺳﯽ ﻧﻘﺎط ﺟﻬﺶ ﯾﺎﻓﺘﻪ ﻣﯿﺘﻮاﻧﺪ در ﺗﺸﺨﯿﺺ و درﻣﺎن ﮐﻤﮏ ﮐﻨﻨﺪه ﺑﺎﺷﺪ. ﺗﻔﺎوت در ﻧﻮﮐﻠﺌﻮﺗﯿﺪﻫﺎي وﯾﺮوس ﻧﻪ ﺗﻨﻬﺎ در ﻣﯿﺰﺑﺎن ﻫﺎ ﻣﺨﺘﻠﻒ ﺑﻠﮑﻪ در ﺳﮑﺎﻧﺲ ﻫﺎي ﺗﻬﯿﻪ ﺷﺪه از ﻧﻤﻮﻧﻪ ﻫﺎي اﻧﺴﺎﻧﯽ در ﮐﺸﻮرﻫﺎي ﻣﺨﺘﻠﻒ ﻣﺘﻔﺎوت اﺳﺖ ﮐﻪ اﯾﻦ ﻣﻮﺿﻮع ﻣﻮﺟﺐ ﺷﺪه ﺗﺎ ﺳﻮال ﻣﻬﻢ در ﻣﻮرد وﯾﺮوس ﮐﻪ ﻫﺮ ﮐﺸﻮر در ﭘﯽ درﻣﺎن، ﺗﺸﺨﯿﺺ و ﺳﺎﺧﺖ واﮐﺴﻦ ﺑﺮاي ﺧﻮد ﺑﺎﺷﺪ قوت ﺑﯿﺸﺘﺮي ﺑﮕﯿﺮد.

The corona virus (COVID-19) is a positive, single-stranded RNA virus. The virus mutates both naturally and after transmission to humans, transmitting it from patients to others, causing an increase in the mutation in its genome. Mutations in the virus have helped it adapt to different conditions and increase the pathogenicity of new individuals. Examination of mutated sites can be helpful in diagnosis and treatment. Differences in virus nucleotides vary not only in different hosts but also in sequences prepared from human samples in different countries, which raises the important question of which virus each country seeks to treat, diagnose, and develop its own vaccine. , Get more strength