تأثير تمرينات تركيبي بر سطح اينترلوكين 6 و برخي پارامترهاي ريوي در جانبازان شيميايي آلوده به گاز خردل

The Effect of Combined Training on Serum Level of Interleukin 6 and Some Pulmonary Parameters in Chemical Veterans Caused By Mustard Gas

ﺑﯿﻤﺎري اﻧﺴﺪاد ﻣﺰﻣﻦ رﯾﻮي )COPD( و آﺳﻢ از اﺻﻠﯽ ﺗﺮﯾﻦ ﻋﻮارض ﺟﺎﻧﺒﯽ ﻗﺮار ﮔﯿﺮي در ﻣﻌﺮض ﮔﺎز ﺧﺮدل ﻣﯽ ﺑﺎﺷﻨﺪ. ﺑﻨﺎﺑﺮاﯾﻦ ﻫﺪف از ﺗﺤﻘﯿﻖ ﺣﺎﺿﺮ ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮﺗﻤﺮﯾﻨﺎﺗﺘﺮﮐﯿﺒﯽ ﻣﻘﺎوﻣﺘﯽ و ﻫﻮازي در آﺑﺒﺮﺳﻄﺤﺎﯾﻨﺘﺮﻟﻮﮐﯿﻦ 6 )6-IL( ﺳﺮم وﺑﺮﺧﯽ ﭘﺎراﻣﺘﺮﻫﺎي رﯾﻮي )FEV1 ،FVC و FEV1/FVC( درﺟﺎﻧﺒﺎزاﻧﺸﯿﻤﯿﺎﯾﯽ آﻟﻮدﻫﮕﺎزﺧﺮدل ﺑﻮد. ﺑﺪﯾﻦ ﻣﻨﻈﻮر 24 ﺟﺎﻧﺒﺎز ﺷﯿﻤﯿﺎﯾﯽ ﻏﯿﺮ ﻓﻌﺎل ﺑﻪ ﻃﻮر ﺗﺼﺎدﻓﯽ در دو ﮔﺮوه ﺗﺠﺮﺑﯽ )12 ﻧﻔﺮ( و ﮐﻨﺘﺮل )12 ﻧﻔﺮ( ﻗﺮار داده ﺷﺪﻧﺪ. ﮔﺮوه ﺗﺠﺮﺑﯽ، ﺗﻤﺮﯾﻨﺎت ﻣﻘﺎوﻣﺘﯽ 3 ﺟﻠﺴﻪ در ﻫﻔﺘﻪ ﺑﺎ ﺷﺪت 70 درﺻﺪ ﺿﺮﺑﺎن ﻗﻠﺐ ذﺧﯿﺮه و ﺗﻤﺮﯾﻨﺎت ﻫﻮازي در آب ﻧﯿﺰ 2 ﺟﻠﺴﻪ در ﻫﻔﺘﻪ ﺑﺎ ﺷﺪت 70 درﺻﺪ ﺿﺮﺑﺎن ﻗﻠﺐ ذﺧﯿﺮه، ﺑﻪ ﻣﺪت 10 ﻫﻔﺘﻪ را اﺟﺮا ﮐﺮدﻧﺪ. ﻧﻤﻮﻧﻪ ﺧﻮن و آزﻣﻮن اﺳﭙﯿﺮوﻣﺘﺮي ﻗﺒﻞ و ﺑﻌﺪ از دوره ﺗﻤﺮﯾﻦ ﮔﺮﻓﺘﻪ ﺷﺪ. داده ﻫﺎي ﺣﺎﺻﻞ ﺑﺎ اﺳﺘﻔﺎده از آزﻣﻮن آﻣﺎري ﺗﯽ واﺑﺴﺘﻪ و ﻣﺴﺘﻘﻞ در ﺳﻄﺢ ﻣﻌﻨﺎداري 0/05

Chronic obstructive pulmonary disease (COPD) and asthma are one of the main side effects of mustard gas exposure. So the propose of present study was survey the effect of combined training of resistance and aerobic training in water on serum level of interleukin 6 (IL-6) and some pulmonary parameters (FVC, FEV1 and FEV1/FVC) in Chemical veterans caused by mustard gas. For this propose, 24 inactive Chemical veterans were selected and randomly divided into experimental (n=12) and control group (n=12). Experimental group did resistance training (3 session per week with 70% heart rate reserve) and aerobic training in water (2 session per week with 70% heart rate reserve) for 10 weeks. Blood sample and spirometry test was done before and after training period. Data was analyses with paired and independent t test at significant level of p<0.05. Data analyzing showed that IL-6 level in experimental group was significantly lower than control group (p=0.020). Also FVC, FEV1 and FEV1/FVC levels n experimental group were significantly higher than control group (p value respectively 0.035, 0.021 and 0.003). reverse and significant relationship were found between IL-6 with FVC (p=0.01), FEV1 (0.001) and FEV1/FVC (0.008). Probably combined training of resistance and aerobic training in water trough reducing inflammatory factor of IL-6 can have beneficial effect on pulmonary index such as FVC, FEV1 and FEV1/FVC levels. Thus this training can be used as complementary therapy in Chemical veterans caused by mustard gas