برﺭﺳﻲ ﻭ ﻣﻌﺮﻓﻲ ﻣﺤﺼﻮﻻﺕ ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ ﺩﺍﺭﺍﻱ ﺗﺄﻳﻴﺪﻳﻪ ﺍﺭﮔﺎﻥﻫﺎﻱ ﻧﻈﺎﺭﺗﻲ ﺟﻬﺖ ﺍﺳﺘﻔﺎﺩﻩ ﺩﺭ ﺩﺭﻣﺎﻥ

OVERVIEW OF BIOLOGIC PRODUCTS WITH MARKETING AUTHORIZATION APPROVAL FOR CLINICAL APPLICATION

ﭘﻴﺶﺯﻣﻴﻨﻪ ﻭ ﻫﺪﻑ: ﺩﺭ ﺑﻴﻦ ﻋﻠﻮﻡ ﻧﻮﻳﻦ ﭘﺰﺷﮑﻲ، ﻃﺐ ﺑﺎﺯﺳﺎﺧﺘﻲ ﺗﻮﺟﻪ ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﻭ ﭘﺰﺷﮑﺎﻥ ﺯﻳﺎﺩﻱ ﺭﺍ ﺑﻪ ﺧﻮﺩ ﺟﻠﺐ ﮐﺮﺩﻩ ﺍﺳﺖ ﺑﻪ ﮔﻮﻧﻪﺍﻱ ﮐﻪ ﺗﻮﺍﻡ ﺑﺎ ﭘﻴﺸﺮﻓﺖ ﺍﻳﻦ ﺷﺎﺧﻪ ﺍﺯ ﭘﺰﺷﮑﻲ، ﺍﻣﻴﺪﻫﺎ ﺑﻪ ﺩﺭﻣﺎﻥ ﺑﻴﻤﺎﺭﻱﻫﺎﻱ ﻏﻴﺮﻗﺎﺑﻞ ﺩﺭﻣﺎﻥ ﻭ ﺻﻌﺐ ﺍﻟﻌﻼﺝ ﺍﻓﺰﺍﻳﺶ ﻳﺎﻓﺘﻪ ﺍﺳﺖ. ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ ﺑﻪﻋﻨﻮﺍﻥ ﺍﻳﺪﻩﺍﻱ ﻧﻮﻳﻦ ﺗﺤﺖ ﺣﻮﺯﻩ ﻃﺐ ﺑﺎﺯﺳﺎﺧﺘﻲ ﺩﺭ ﺗﻌﺎﻣﻞ ﺑﺎ ﻣﻬﻨﺪﺳﻲ ﺑﺎﻓﺖ ﻭ ﮊﻧﺘﻴﮏ ﺗﻮﺍﻧﺴﺘﻪ ﺍﺳﺖ ﮔﻮﻱ ﺳﺒﻘﺖ ﺭﺍ ﺩﺭ ﻋﻠﻮﻡ ﻧﻮﻳﻦ ﭘﺰﺷﮑﻲ ﺭﺑﻮﺩﻩ ﻭ ﺗﺄﻳﻴﺪﻳﻪ ﺍﺳﺘﻔﺎﺩﻩ ﺑﺎﻟﻴﻨﻲ ﭼﻨﺪﻳﻦ ﻣﺤﺼﻮﻝ ﺩﺍﺭﻭﻳﻲ ﺑﺮ ﭘﺎﻳﻪ ﺳﻠﻮﻟﻲ ﺭﺍ ﺭﻭﺍﻧﻪ ﺑﺎﺯﺍﺭ ﻣﺼﺮﻑ ﮐﻨﺪ. ﻫﺪﻑ ﺍﺯ ﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ، ﻣﻌﺮﻓﻲ ﻭ ﻣﺮﻭﺭ ﺩﺍﺭﻭﻫﺎﻱ ﺗﺄﻳﻴﺪ ﺷﺪﻩ ﻣﺒﺘﻨﻲ ﺑﺮ ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ ﺍﺳﺖ ﮐﻪ ﺍﻣﺮﻭﺯﻩ ﻣﻮﺭﺩ ﺍﺳﺘﻔﺎﺩﻩ ﺩﺭﻣﺎﻧﻲ ﻗﺮﺍﺭ ﮔﺮﻓﺘﻪ ﺍﺳﺖ. ﻣﻮﺍﺩ ﻭ ﺭﻭﺵﻫﺎ: ﺍﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺍﺯ ﻧﻮﻉ ﻣﺮﻭﺭﻱ ﻏﻴﺮﺳﻴﺴﺘﻤﻴﮏ ﺑﻮﺩﻩ ﮐﻪ ﻃﻲ ﺁﻥ ﺗﻤﺎﻣﻲ ﻣﺤﺼﻮﻻﺕ ﺑﻴﻮﻟﻮﮊﻳﮏ ﺩﺍﺭﺍﻱ ﺗﺄﻳﻴﺪﻳﻪ ﺍﺳﺘﻔﺎﺩﻩ ﺩﺭﻣﺎﻧﻲ ﺩﺭ ﺳﻄﺢ ﺟﻬﺎﻥ ﺍﺯ ﺳﺎﻳﺖﻫﺎﻱ ﻣﺮﺑﻮﻁ ﺑﻪ ﺳﺎﺯﻣﺎﻥﻫﺎﻱ ﻣﺮﺑﻮﻃﻪ ﺍﺳﺘﺨﺮﺍﺝ ﻭ ﮔﺰﺍﺭﺵ ﮔﺮﺩﻳﺪﻩ ﺍﺳﺖ. ﻫﻤﭽﻨﻴﻦ ﺟﺴﺘﺠﻮﻱ ﻣﻘﺎﻻﺕ ﺑﻪ ﺷﻴﻮﻩ ﺩﺳﺘﻲ ﻭ ﺍﻟﮑﺘﺮﻭﻧﻴﮑﻲ ﺩﺭ ﭘﺎﻳﮕﺎﻩﻫﺎﻱ ﺍﻃﻼﻋﺎﺗﻲ PubMed، Scopusﻭ Science Direct ﺍﻧﺠﺎﻡ ﮔﺮﻓﺖ. ﻳﺎﻓﺘﻪﻫﺎ: ﺍﺯ ﺁﻧﺠﺎﻳﻲ ﮐﻪ ﻣﺤﺼﻮﻻﺕ ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ ﺑﺎ ﻓﺮﺍﻭﺭﺩﻩﻫﺎﻱ ﻣﺒﺘﻨﻲ ﺑﺮ ﮊﻥ ﺩﺭﻣﺎﻧﻲ ﻭ ﻣﻬﻨﺪﺳﻲ ﺑﺎﻓﺖ ﻗﺮﺍﺑﺖ ﺩﺍﺭﺩ، ﮐﻠﻴﻪ ﻓﺮﺍﻭﺭﺩﻩﻫﺎﻱ ﺑﻴﻮﻟﻮﮊﻳﮏ ﺩﺍﺭﺍﻱ ﺗﺄﻳﻴﺪﻳﻪ ﺍﺳﺘﻔﺎﺩﻩ ﺑﺎﻟﻴﻨﻲ ﺍﺯ ﮐﺸﻮﺭﻫﺎﻱ ﻣﺨﺘﻠﻒ ﺟﻬﺎﻥ ﺟﻤﻊ ﺁﻭﺭﻱ ﻭ ﻣﻌﺮﻓﻲ ﺷﺪﻩﺍﺳﺖ. ﺩﺭ ﻣﺠﻤﻮﻉ ﺍﻳﺎﻻﺕ ﻣﺘﺤﺪﻩ ﺑﺎ 16 ﻣﺤﺼﻮﻝ، ﮐﺮﻩ ﺟﻨﻮﺑﻲ ﺑﺎ 14 ﻣﺤﺼﻮﻝ ﻭ ﺍﺗﺤﺎﺩﻳﻪ ﺍﺭﻭﭘﺎ ﺑﺎ 8 ﻣﺤﺼﻮﻝ ﺑﻪ ﺗﺮﺗﻴﺐ ﺑﻴﺸﺘﺮﻳﻦ ﺗﻌﺪﺍﺩ ﺍﻳﻦ ﻣﺤﺼﻮﻻﺕ ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ ﺭﺍ ﺩﺍﺭﺍ ﻣﻲﺑﺎﺷﻨﺪ. ﻧﺘﻴﺠﻪ ﮔﻴﺮﻱ: ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﺗﺎﺯﮔﻲ ﺍﻳﻦ ﺷﺎﺧﻪ ﺍﺯ ﭘﺰﺷﮑﻲ ﻭ ﻭﺭﻭﺩﻣﺤﺼﻮﻻﺕ ﻣﺒﺘﻨﻲ ﺑﺮ ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ ﺑﻪ ﺑﺎﺯﺍﺭ ﻣﺼﺮﻑ، ﻳﮏ ﺭﻭﻧﺪ ﺻﻌﻮﺩﻱ ﺩﺭ ﺗﻮﻟﻴﺪﺍﺕ ﻭ ﺗﻮﺟﻬﺎﺕ ﺑﻪ ﺁﻳﻨﺪﻩ ﭘﺰﺷﮑﻲ ﺑﺎﺯﺳﺎﺧﺘﻲ ﻭ ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ ﻗﺎﺑﻞ ﭘﻴﺶ ﺑﻴﻨﻲ ﺍﺳﺖ. ﻭﺍﮊﻩﻫﺎﻱ ﮐﻠﻴﺪﻱ: ﻃﺐ ﺑﺎﺯﺳﺎﺧﺘﻲ، ﺳﻠﻮﻝ ﺩﺭﻣﺎﻧﻲ، ﻣﺤﺼﻮﻻﺕ ﺑﻴﻮﻟﻮﮊﻳﮏ

Background & Aims: Among the different fields of modern medical sciences, regenerative medicine has attracted the attention of many researchers and physicians. The development of this branch of medicine has increased hopes for the treatment of incurable diseases. As a new idea in regenerative medicine in interaction with tissue engineering and genetics, cell therapy has been able to snatch the lead in modern medical sciences and confirm the clinical use of several cell-based pharmaceutical products. Cell therapy aims to transplant healthy human cells to replace or repair damaged cells for therapeutic purposes. Hence, this study aims to introduce and review approved cell-based drugs that are currently used in therapy. Materials & Methods: This study is a non-systematic review in which all biological products with therapeutic approval worldwide were extracted and reported from relevant organizations' sites. Articles were also searched manually and electronically in PubMed, Scopus, and Science Direct databases. Results: Since cell therapy products are related to products based on gene therapy and tissue engineering, all biological products with clinical use approval were collected and introduced from different countries. In total, the United States with 16 products, South Korea with 14 products, and the European unio‎n with 8 products had the highest number of cell therapy products, respectively. Conclusion: Due to the novelty of this branch of medicine and the entry of cell therapy-based products into the consumer market, a rising trend in production and attention to the future of reconstructive medicine and cell therapy is predictable