اثر تمرين شنا همراه با عصاره گشنيز بر شاخص هاي قندي موش هاي صحرايي مبتلا به ديابت

The Effect of Swimming Training With Coriandrum Sativum Extract on Glycemic Indices in Diabetic Rats

مقدمه و هدف: فعاليت­ هاي ورزشي و رژيم غذايي سهم عمده­اي در كاهش عوارض ناشي از ديابت از جمله چاقي، پر فشار خوني، هيپرليپيدمي و هيپرانسولينمي دارند. هدف از تحقيق حاضر بررسي اثر تمرين شنا همراه با مصرف عصاره گشنيز بر شاخص­ هاي قندي موش­هاي صحرايي مبتلا به ديابت بود. مواد و روش ­ها: در اين پژوهش تجربي 32 سر موش صحرايي نژاد اسپراگودوالي انتخاب و يك هفته پس از القاء ديابت به چهار گروه 8 سري 1) تمرين شنا، 2) گشنيز، 3) تمرين شنا همراه با گشنيز، و 4) كنترل تقسيم شدند. گروه ­هاي 2 و 3 روزانه 100 ميلي گرم به ازاي هر كيلوگرم وزن بدن عصاره گشنيز به صورت صفاقي دريافت كردند همچنين گروه هاي 1 و 3 به مدت چهار هفته و هر هفته پنج جلسه و هر جلسه به مدت 30 دقيقه شنا كردند. جهت تجزيه و تحليل يافته ­ها، از آزمون­هاي كالموگروف- اسميرنوف، تحليل واريانس يك راهه همراه با آزمون تعقيبي توكي استفاده شد (0/05 ≥P). يافته ­ها: تمرين شنا، مصرف گشنيز و تمرين شنا همراه با مصرف گشنيز اثر معني­ داري بر كاهش گلوكز ناشتا و هموگلوبين گليكوزيله داشت (0/05≥P)؛ مصرف گشنيز و تمرين شنا همراه با مصرف گشنيز اثر معني­ داري بر كاهش مقاومت به انسولين داشت (0/05≥P)؛ مصرف گشنيز نسبت به تمرين شنا اثر بيشتري بر كاهش گلوكز ناشتا داشت (0/05≥P) و تمرين شنا، مصرف گشنيز و تمرين شنا همراه با مصرف گشنيز اثر معني ­داري بر كاهش انسولين نداشت (0/05≤P). بحث و نتيجه ­گيري: به نظر مي­ رسد بتوان جهت بهبود شاخص­ هاي قندي موش ­هاي صحرايي مبتلا به ديابت از چهار هفته تمرين شنا و مصرف عصاره گشنيز استفاده نمود.

Introduction: Exercises and nutrition regimen have a major portion in the reduction of diabetes induced complications such as obesity, hypertension, hyperlipidemia and hyper- insulinemia. The Aim of the present study was to investigate the effect of swimming training with consuming Coriandrum Sativum extract on glycemic indices of diabetic rats. Materials and Methods: 32 Sprague- Dawley rats were randomly selected in this experimental research, and one week after the induction of diabetes, they were divided into four groups of 8 rats. These groups include: 1) swimming training, 2) Coriandrum Sativum, 3) swimming training with Coriandrum Sativum, and 4) control group. Groups 2 and 3 received 100 mg/kg Coriandrum Sativum peritoneally. Also, groups 1 and 3 swam for 4 weeks, five sessions per-week. -Each session lasted 30 minutes. In this study, Kolmogorov- Smirnov test, one way ANOVA and Tukey’s post- hoc tests were used for the statistical analysis of data (p≤0.05). Findings: Swimming training, consumption of Coriandrum Sativum, and swimming training with Coriandrum Sativum had a significant effect on the reduction of fasting glucose and glycosylated hemoglobin (p≤0.05). In addition, Coriandrum Sativum and swimming training with Coriandrum Sativum had a significant effect on the reduction of insulin resistance (p≤0.05) . Furthermore, Coriandrum Sativum had more favorable effects on the reduction of fasting glucose compared with the swimming training (p≤0.05) and swimming training, Coriandrum Sativum, and swimming training with Coriandrum Sativum had no significant effect on the reduction of insulin (p≥0.05). Conclusion: It seems that it is possible to use 4 weeks swimming training with Coriandrum Sativum in order to improve glycemic indices in diabetic rats.