مقايسه ميزان نسبت پلاكت به لنفوسيت و نوتروفيل به لنفوسيت در بيماران مبتلا به آرتريت روماتوييد با و بدون عوارض چشمي

The evaluation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with rheumatoid arthritis with and without ocular complications

در بررسي وضعيت بيماران آرتريت روماتوييد فاكتورهاي التهابي مانند پروتئين واكنشگر C، سرعت رسوب گلبول هاي قرمز، ميزان فعاليت بيماري و به ويژه نسبت پلاكت به لنفوسيت و نسبت نوتروفيل به لنفوسيت داراي اهميت مي باشند. در اين مطالعه نسبت پلاكت به لنفوسيت و نسبت نوتروفيل به لنفوسيت در دو گروه بيماران با و بدون عوارض چشمي مقايسه گرديد. روش بررسي اين مطالعه يك بررسي تحليلي-مقطعي است كه روي 246 بيمار مبتلا به آرتريت روماتوييد مراجعه كننده به كلينيك روماتولوژي كرمانشاه در بازه زماني آذر 1397 تا ارديبهشت 1398 و با كد اخلاق (IR.KUMS.REC1397.311) انجام شده است. 191 نفر از بيماران بدون عوارض چشمي و 55 بيمار دچار عوارض چشمي بودند و از نظر سن و جنس همسان سازي شدند. شمارش سلول هاي خوني با دستگاه Sysmex KX-21 hematology analyzer انجام گرفت. نسبت پلاكت به لنفوسيت و نسبت نوتروفيل به لنفوسيت با آزمون همبستگي اسپيرمن و ميزان فعاليت بيماري بين دو گروه با Mann-Whitney U test مقايسه گرديد. يافته ها بررسي نتايج اين مطالعه اختلاف معناداري بين سطح نوتروفيل به لنفوسيت و پلاكت به لنفوسيت در دو گروه با و بدون عوارض چشمي نشان نداد. اما ميزان فعاليت بيماري در گروه با عوارض چشمي به طور معناداري پايين تر از گروه بدون عوارض چشمي بود (0/001

Rheumatoid Arthritis patients are evaluated during treatment for various inflammatory factors such as C-reactive protein, Erythrocyte Sedimentation Rate, and Disease Activity Score, and other immune system-related factors. In the follow-up of patients with rheumatoid arthritis, hematologic factors associated with the immune system especially Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio are important. In this study, platelet to lymphocyte ratio and Neutrophil to lymphocyte ratio were compared in two groups of patients with and without ocular complications. Methods This cross-sectional study was performed on 246 patients with rheumatoid arthritis who were referred to the rheumatology clinic of Kermanshah from December 2018 to May 2019. This study was carried out in accordance with the approval of the ethics committee (IR.KUMS.REC1397.311) at Kermanshah University of Medical Sciences. Of these patients, 191 had no ocular complications and 55 patients had ocular complications and were matched for age and sex. The blood samples were taken from patients and blood cell count was measured by Sysmex KX-21 hematology analyzer. The Spearman correlation test was used to evaluate the relationship between platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in both groups of patients without ocular complications and with ocular complications. The Disease Activity Score was compared between the two groups using the Mann-Whitney test. Results The results of this study showed no significant difference between NLR and PLR levels in both groups of patients without ocular complications and with ocular complications. But the results showed that DAS-28 was significantly lower in the group with ocular complications (P<0.0001). Conclusion In general, the results of the present study showed that the evaluation of inflammatory factors such as platelet to lymphocyte ratio and neutrophil to lymphocyte alone could not be judged in predicting the presence or possibility of ocular involvement, and the level of these factors in patients with ocular complications was affected. Other factors, such as the number of blood cells and the condition of each patient, are included.