ﺑﺮرﺳﯽ اﺛﺮات ﺗﺠﻮﯾﺰ اﭘﯿﺪورال دﯾﮑﻠﻮﻓﻨﺎك ﺳﺪﯾﻢ ﺑﺮ ﺑﺮﺧﯽ از ﻓﺮاﺳﻨﺠﻪﻫﺎي ﻫﻤﺎﺗﻮﺑﯿﻮﺷﯿﻤﯿﺎﯾﯽ، ﻋﻼﯾﻢ ﺣﯿﺎﺗﯽ، ﻓﻌﺎﻟﯿﺖ اﻟﮑﺘﺮﯾﮑﯽ ﻗﻠﺐ و ﺑﯽ دردي در ﮔﻮﺳﻔﻨﺪ

Evaluation of epidural administration of diclofenac sodium on analgesia in sheep and its effect on hematobiochemical parameters, vital signs and activity of the heart

اﯾـﻦ ﭘـﮋوﻫﺶ ﺑـﺮاي ﺑﺮرﺳـﯽ ﺑـﯽ دردي و اﺛـﺮات ﺟـﺎﻧﺒﯽ دﯾﮑﻠﻮﻓﻨـﺎك ﺳـﺪﯾﻢ ﺑـﻪ روش اﭘﯿـﺪورال روي ﻋﻼﯾـ ﻢ ﺣﯿـﺎﺗﯽ، ﻓﺮاﺳـﻨﺠﻪ ﻫـﺎي ﻫﻤﺎﺗﻮﺑﯿﻮﺷﯿﻤﯿﺎي و ﻣﻮﻟﻔﻪﻫﺎي اﻟﮑﺘﺮوﮐﺎردﯾﻮﮔﺮاﻓﯽ در ﮔﻮﺳﻔﻨﺪان ﻧﮋاد ﻟﺮي اﻧﺠﺎم ﺷﺪ. 18 راس ﮔﻮﺳﻔﻨﺪ ﻣﺎده ﻏﯿﺮ آﺑﺴﺘﻦ ﺳـﺎﻟﻢ )3/2±00/46 ﺳﺎل( ﺑﻪ ﻃﻮر ﺗﺼﺎدﻓﯽ ﺑﻪ ﺳﻪ ﮔﺮوه ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ و ﻟﯿﺪوﮐﺎﺋﯿﻦ )5 ﻣﯿﻠﯽ ﮔﺮم ﺑﻪ ازاي ﮐﯿﻠﻮﮔﺮم(، دﯾﮑﻠﻮﻓﻨـﺎك ﺳـﺪﯾﻢ )5 ﻣﯿﻠـﯽ ﮔـﺮم ﺑـﻪ ازاي ﮐﯿﻠﻮﮔﺮم( ﯾﺎ ﺗﺮﮐﯿﺐ ﻟﯿﺪوﮐﺎﺋﯿﻦ )5 ﻣﯿﻠﯽ ﮔﺮم ﺑﻪ ازاي ﮐﯿﻠﻮﮔﺮم( - دﯾﮑﻠﻮﻓﻨﺎك ﺳﺪﯾﻢ )5 ﻣﯿﻠﯽ ﮔﺮم ﺑﻪ ازاي ﮐﯿﻠﻮﮔﺮم( را در ﻓﻀﺎي ﺑـﯿﻦ ﻣﻬـﺮه ﯾﮏ و دو دﻣﯽ درﯾﺎﻓﺖ ﮐﺮدﻧﺪ. زﻣﺎن ﺷﺮوع ﺑﯽﺣﺴﯽ و ﻃﻮل ﻣﺪت ﺑﯽ ﺣﺴﯽ در ﻧﻮاﺣﯽ دﻧﺒﻪ، ﻣﻘﻌﺪ، ﭘﺮﯾﻨﻪ، ﻓﺮج و ﻧﺎﺣﯿﻪ داﺧﻠﯽ رانﻫﺎ ﺑﺎ ﺗﺴـﺖ ﺳﻮزن ﺑﺮرﺳﯽ ﺷﺪ. ﻋﻼﯾﻢ ﺣﯿﺎﺗﯽ ﻗﺒﻞ و در زﻣﺎنﻫﺎي 5، 15، 30، 45، 60، 90 و 120 دﻗﯿﻘﻪ، ﭘﺲ از ﺗﺰرﯾﻖ اﭘﯿﺪورال ﺛﺒﺖ ﺷﺪ، ﻫﻤﭽﻨـﯿﻦ در زﻣﺎن ﻫﺎي 30، 60 و 120 دﻗﯿﻘﻪ ﻧﻮار ﻗﻠﺒﯽ، درﺻﺪ اﺷﺒﺎع اﮐﺴﯿﮋن ﺷﺮﯾﺎﻧﯽ و ﻧﻤﻮﻧﻪ ﺧﻮن ورﯾﺪي از ﺗﻤﺎم ﮔﻮﺳﻔﻨﺪان اﺧﺬ ﮔﺮدﯾﺪ. زﻣـﺎن ﺷـﺮوع ﺑﯽ ﺣﺴﯽ و ﻃﻮل ﻣﺪت زﻣﺎن ﺑﯽ ﺣﺴﯽ در ﮔﺮوه دﯾﮑﻠﻮﻓﻨﺎك ﺳﺪﯾﻢ ﻧﺴﺒﺖ ﺑﻪ دو ﮔﺮوه دﯾﮕﺮ ﺑﻪ ﻃﻮر ﻣﻌﻨﯽداري ﺑﻪ ﺗﺮﺗﯿﺐ ﻃﻮﻻﻧﯽﺗﺮ و ﮐﻮﺗﺎهﺗـﺮ ﺑﻮد )0/05< P(. ﻧﺘﺎﯾﺞ ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﻧﺸﺎن داد دﯾﮑﻠﻮﻓﻨﺎك ﺳﺪﯾﻢ ﻫﻤﺮاه ﺑﺎ ﻟﯿﺪوﮐﺎﺋﯿﻦ ﮐﯿﻔﯿﺖ ﺑﯽ ﺣﺴﯽ اﭘﯿﺪورال در ﮔﻮﺳﻔﻨﺪ را اﻓﺰاﯾﺶ ﻣﯽ-دﻫﺪ و اﺛﺮ ﻣﻨﻔﯽ روي ﻣﻮﻟﻔﻪﻫﺎي ﻧﻮار ﻗﻠﺒﯽ و ﻏﻠﻈﺖ اﮐﺴﯿﮋن اﺷﺒﺎع ﺷﺮﯾﺎﻧﯽ ﻧﺪارد، اﻣﺎ ﻣﻮﺟﺐ ﮐﺎﻫﺶ ﻏﻠﻈﺖ ﻫﻤﺎﺗﻮﮐﺮﯾﺖ، ﺗﻌـﺪاد ﮔﻠﺒـﻮل ﻫـﺎي ﻗﺮﻣﺰ و ﮔﻠﺒﻮلﻫﺎي ﺳﻔﯿﺪ ﺧﻮن ﻣﯽﺷﻮد، ﺑﻨﺎﺑﺮاﯾﻦ ﺑﻪ ﮐﺎرﮔﯿﺮي دﯾﮑﻠﻮﻓﻨﺎك ﺳﺪﯾﻢ در ﺑﯽﺣﺴﯽ اﭘﯿﺪورال ﺗﻮام ﺑﺎ ﻟﯿﺪوﮐﺎﺋﯿﻦ ﯾﺎ ﻣﻨﻔﺮد در ﮔﻮﺳﻔﻨﺪ ﺗﻮﺻﯿﻪ ﻧﻤﯽﺷﻮد.

This study was performed to evaluate analgesia and side effects of diclofenac sodium on vital signs, hematobiochemical parameters and electrocardiographic indices in Lori sheep after epidural anesthesia. Eighteen non-pregnant healthy sheep (3.00±2.46 years old) haphazardly separated into three groups and received the lidocaine (5 mg/kg), diclofenac sodium (5 mg/kg) or lidocaine (5 mg/kg) plus diclofenac sodium (5 mg/kg) via epidural injection into the first intercoccygeal space. Analgesia onset time and duration were recorded by needle testing on the tail, anus, perineum, vulva and inner thighs. Vital signs were recorded after epidural administration at 5, 15, 30, 45, 60, 90, and 120 minutes. Also, electrocardiography, blood oxygen saturation levels and venous blood samples were taken from all sheep at 30, 60 and 120 minutes. Onset and duration of analgesia in the diclofenac group was significantly longer and shorter than the other groups (p<0.05), respectively. The results of this study showed that diclofenac sodium with lidocaine increases the quality of epidural analgesia in sheep and has no negative effect on electrocardiogram (ECG) components and arterial oxygen saturation (SPO2). But it decreases Packed cell volume concentration (PCV), red blood cells (RBC) and white blood cells (WBC) count. Therefore, due to these changes, using of diclofenac sodium for epidural anesthesia in sheep is not recommended with or without lidocaine.