IVF/ICSI ارتباط سطح پرولاكتين سرم در زمان برداشت تخمك با ميزان موفقيت حاملگي در باروري آزمايشگاهي

The relationship between serum prolactin on the day of oocyte puncture and pregnancy rate in vitro fertilization/Intracytoplasmic sperm injection

There is no agreement about the effect of temporary hyperprolactinemia on the day of ovum pick up(OPU) on pregnancy rate in assisted reproductive treatments. In order to determine the association of serum prolactin on the day of OPU with pregnancy rate in IVF/ICSI methods, this study was carried out on infertile women, admitted to Valie-Asr Hospital through the years of 1998-1999. In 151 eligible women, stimulation was conducted according to the Long Protocol. Then, serum prolactin was measured on the day ofHCG injection and OPU. The results of the study showed that serum prolactin was <25 ng/ml in 91 patients (group I) and >25ng/ml in 60 patients (group II). There wasnʹt any statistically significant differences between two groups regarding maternal age, kind and cause of infertility, the number of mature follicles (>13 mm) and mature oocytes. The number of embryo and their cleavage rate was similar in both groups. There was a significant difference between two groups regarding the maturation rate of embryos. Grade A (suitable cell maturation) was seen in 90% of group II and 77% in group I (P=0.019). The pregnancy rate was significantly higher in group II than group I (28.3% versus 3.3%, P=0.00001). In logistic regression model the serum prolactin (P=0.0150) and quality of embryo (P-0.140) had a significant association with pregnancy rate.