HIV/AIDS مثبت مراجعه كننده به مركز مشاوره و مراقبت HIV ميزان شيوع ترومبوسيتوپني در بيماران

Thrombocytopenia in HIV infected patients: a report from the HIV/AIDS Counseling and Care Center

Thrombocytopenia is one of the common AIDS-related blood dyscrasia that is postulated to be in relation with increased viral load and diminished CD+4 Tlymphocytes. We evaluated the rate of Thrombocytopenia (Plt< 100,000) in 170 HIV infected patients from May 2000 until April 2001 in Kermanshah province, Iran. In a cross-sectional study from all HIV positive patients in whom infection had been confirmed by ELISAI,II or western blot test a blood sample was and obtained. The samples were investigated for platelet then, CD+ T-cells were determind by flowcytometry. From 170 patients, 161 cases (94.71%) were male and 9(5.3%) female. All males and 2 females were drug abusers. The rate of Thrombocytopenia in this study was 20%(34 of 170 patients) of them, three had severe thrombocytopenia(plt<20,000). Although, the prevalence of thrombocytopenia was similar in various stages of HIV infection (18.5%) , the severe form of thrombocytopenia was found in patients with CD+4 T-cell count of less than 200/ml. There was no associated infection, drug consumption, spleenomegaly or other conditions to cause thrombocytopenia in the patients except for HIV infection. None of the patients developed clinical complications except one for whom spleenectomy was performed with the result of complete recovery. We conclude that mild thrombocytopenia is common in HIV infected patients in the region and the rate of thrombocytopenia is similar in different stages of HIV infection but severe different types are common in advanced phase.