كاهش عوارض قلبي و عروقي به هنگام خارج كردن لوله تراشه با استفاده از كلونيدين خوراكي بعنوان پيش دارو

Clonidine decreases cardiovascular alterations during tracheal extubation

Introduction: Tracheal extuhation may he accompanied by cardiovascular alterations such as hypertension, tachycardia, etc which can be dangerous in high-risk patients. In this study the effects of oral clonidine, as a premedication, on the reduction of cardiovascular complications following tracheal extubation was evaluated. Methods: In a double-blind clinical trial, 99 patients candidated for elective upper extremity surgery at the end of general anesthesia were divided into 3 groups. Patients received premedication 0.2 mg oral clonidine (group 1), 0.4 mg clonidine (group 2) and vitamin B6 as a placebo (group 3). Alterations in blood pressure and heart rate five minutes pre- and post- extuhation and during extubation were recorded. Results: Homodynamic instability was reduced in groups receiving oral clonidine in comparison with control group. Conclusions: There was no significant difference between the two groups of 0.2 mg versus 0.4 mg oral clonidine in blunting deleterious hemodynamic effects during extuhation. We recommended the use of 0.2mg oral clonidine in patients who are at risk of cardiovascular disease.