در زنان سنين باروري ، نوجوانان و كودكان در شهر تهران Parvovirus B91 بررسي سرواپيدميولوژيك عفونت

Seroepidemiological survey of human parvovirus B19 infection among childbearing women and children in Tehran

Human parvovirus B19 is one of the aetiological agents of fetal death. The study of intrauterine B19 virus infection, suggests that B19 virus could have a teratogenic effect in humans. Parvovirus B19 is distributed worldwide, and over 50% of individuals have IgG antibody to B19 virus by the age of 20 years. The level of immunity to viral infections in women of childbearing age varies among different populations, and is an important factor in determining the incidence of intrauterine infections, A seroepidemiological survey was carried out to determine the prevalence of parvovirus B19 antibody in 2185 healthy < 15 years old chidren and 15-45 year old females from 1995 to 1997 in Tehran, Anti-B19 Virus IgG was investigated by an indirect enzyme immunoassay (IDEIA) in sera of individuals. The overall prevalence of B19 antibody was 91% in children and adult females. There was a high maternal passive immunity to B19 virus under 6 months of age. Over 50% of males and females had been exposed to B19 virus by the age of 4 years, which shows that the age of occurance of B119 infection is low in Tehran, Approximately 80% of children had anti-B19 virus IgG by the age of 14 years with no significant sex difference. The seroprevalence of anti-B19 virus IgG was about 93% among childbearing women in Tehran, and the rate of specific IgG increased with age. The immunity levels to B19 virus in childbearing women belonging to north and south of Tehran were 90% and 93,3% respectively with no statistically significant difference. Finally, the high prevalence of parvovirus 2?19 antibody in reproductive women indicates that there is a low risk of intrauterine fetal death caused by Parvovirus JB19 in Tehran,