اثر تجويز روي تكميلي بر وضعيت شاخص هاي كنترل متابوليك در كودكان مبتلا به ديابت نوع يك

Effects of zinc supplementation on metabolic control indices in children with type I diabetes

Introduction: Marginal zinc (Zn) deficiency due to hyper-zincuria is possible in patients with diabetes mellitus (DM). Zn supplementation, therefore, can he regarded as a suitable "back up" strategy in the management of DM. In this 11-week double-masked clinical trial we investigated the effects of a low-strength Zn sulfate supplement on metabolic control indices in children with type I DM. Methods: Thirty-one 5-15 years children with at least 1.5 year DM history, without any other metabolic condition were randomly divided into Zn-supplemented (10 mg elemental Zn per day) and/or placebo groups after matching for sex, age and DM duration. Twenty-six children fulfilled the study. Weight, fasting blood sugar (FBS), glycosylated hemoglobin (Mille), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) and triglyceride (TG), levels were determined at the beginning and end of trial. Results: In Placebo group, HbAIc., FBS, TC, LDL-e, HDL-c and TG levels changed from 9.7+0.4 to 1010.5%, 243+26 to 241122 mg/dl, 160+6 to 154+7 mg/dl, 95+23 to 93+19 mg/ell, 5114 to 45+2 mg/dl and 68+7 to 85+12 mg/di, respectively. Corresponding values .for Zn supplemented group were 9.9+0.5 to 10+0.5%, 250+23 to 217+36 mg/dl, 176+6 to 16+16 mg/dl, 113+19 to 91+14 mg/dl, 55+5 to 47+3 mg/dl and 88+12 to 95+13 mg/di, respectively. Only serum LDL-c significantly decreased within Zn supplemented group (P<0.003). Conclusion: It seems that low-dose Zn supplementation is a safe compensatory strategy for h} per zincur iu in patients with type I DM.