ﺗﺎﺛﯿﺮاﺛﺮات ﻣﻬﺎري ﻋﺼﺎره ﮔﯿﺎه داروﯾﯽ ﻋﺮوﺳﮏ ﭘﺸﺖ ﭘﺮده Physalis alkekengi ﺑﺮ روي ﺳﺮﻃﺎن ﭘﺮوﺳﺘﺎت ﻧﺎﺷﯽ از ﺗﺰرﯾﻖ DMBA در ﻣﻮش

Inhibitory effects of Physalis alkekengi on the prostate cancer caused by DMBA injection in mice

ﺗﺎ ﮐﻨﻮن ﻣﻄﺎﻟﻌﺎت ﮔﺴﺘﺮده اي از اﺛﺮات درﻣﺎﻧﯽ ﮔﯿﺎﻫﺎن ﻣﺨﺘﻠﻒ ﺑﺮ اﻧﻮاع ﺳﺮﻃﺎن ﺻﻮرت ﮔﺮﻓﺘﻪ اﺳﺖ. ﻫﺪف از اﯾﻦ ﻣﻄﺎﻟﻌﻪ، ﺑﺮرﺳﯽ اﺛﺮات ﻋﺼﺎره ﻫﯿﺪرواﻟﮑﻠﯽ ﺳﺮﺷﺎﺧﻪ ﻫﺎي ﻫﻮاﯾﯽ ﮔﯿﺎه ﻋﺮوﺳﮏ ﭘﺸﺖ ﭘﺮده)Physalis alkekengi( ﺑﺮ ﺳﺮﻃﺎن ﭘﺮوﺳﺘﺎت ﻧﺎﺷﯽ از ﺗﺰرﯾﻖ داروي ﺳﺮﻃﺎن زاي 12,7 دي ﻣﺘﯿﻞ ﺑﻨﺰآﻧﺘﺮاﺳﻦ )DMBA(، در ﻣﻮش اﺳﺖ. در اﯾﻦ ﭘﮋوﻫﺶ ﭘﺲ از اﻟﻘﺎي ﺑﯿﻬﻮﺷﯽ در ﻣﻮش ﻫﺎي ﻣﻮرد آزﻣﺎﯾﺶ، ﺗﺰرﯾﻖ ﻣﺴﺘﻘﯿﻢ DMBA ﺑﻪ ﻏﺪه ﭘﺮوﺳﺘﺎت ﻣﻮش ﻫﺎي ﻧﺮ اﻧﺠﺎم ﺷﺪ و ﭘﺲ از ﮔﺬﺷﺖ 10 روز، ﻫﺮ 48 ﺳﺎﻋﺖ و ﺗﺎ ﭘﺎﯾﺎن روز ﺑﯿﺴﺖ و ﯾﮑﻢ، ﻣﻮش ﻫﺎي درﯾﺎﻓﺖ ﮐﻨﻨﺪه دارو، ﻣﻘﺎدﯾﺮ ﻣﺘﻔﺎوت از ﻋﺼﺎره ي ﻋﺮوﺳﮏ ﭘﺸﺖ ﭘﺮده ﺑﻪ ﺻﻮرت ﺗﺰرﯾﻖ درون ﺻﻔﺎﻗﯽ درﯾﺎﻓﺖ ﮐﺮدﻧﺪ. در ﮔﺮوه ﮐﻨﺘﺮل ﺗﺰرﯾﻖ درون ﺻﻔﺎﻗﯽ ﻧﺮﻣﺎل ﺳﺎﻟﯿﻦ اﻧﺠﺎم ﺷﺪ. ﻧﺸﺎن داد ﮐﻪ ﻋﺼﺎره ﻋﺮوﺳﮏ ﭘﺸﺖ ﭘﺮده ﺑﻪ وﯾﮋه در دو ﻏﻠﻈﺖ )500 و1000( وزن ﭘﺮوﺳﺘﺎت را ﺑﻄﻮر ﻣﻌﻨﯽ داري ﮐﺎﻫﺶ داد. ﻫﻤﭽﻨﯿﻦ ﺗﻐﯿﯿﺮات ﺑﺎﻓﺖ آﺳﯿﺐ ﺷﻨﺎﺳﯽ در ﺗﻮﻣﻮرﻫﺎي ﭘﺮوﺳﺘﺎت ﮔﺮوه ﻫﺎي ﺗﺤﺖ درﻣﺎن ﺑﺎ ﻋﺼﺎرهPhysalis alkekengi در ﻣﻘﺎﯾﺴﻪ ﺑﺎ ﮔﺮوه ﮐﻨﺘﺮل ﻣﺸﺎﻫﺪه ﺷﺪ. ﺑﻪ ﻧﻈﺮ ﻣﻲ رﺳﺪ ﮐﻪ ﻋﺼﺎره ﻫﯿﺪرواﻟﮑﻠﻲ ﻋﺮوﺳﮏ ﭘﺸﺖ ﭘﺮده، رﺷﺪ ﻏﯿﺮﻃﺒﯿﻌﻲ، ﺿﺎﯾﻌﺎت ﭘﯿﺶ ﺳﺮﻃﺎﻧﻲ و ﮐﺎرﺳﯿﻨﻮم ﻧﺎﺷﻲ از DMBA را در ﭘﺮوﺳﺘﺎت ﻣﻮش ﻧﮋاد BALB/c ﻣﻬﺎر و درﻣﺎن ﻣﻲ ﮐﻨﺪ.

So far, extensive studies have been performed on different types of cancer. The aim of this study was to evaluate the effect of hydroalcoholic extract of the aerial branches of Physalis alkekengi based on the king's recommendations of injecting the carcinogenic drug 12.7 dimethylbenzanthracene (DMBA) in mice. After induction of anesthesia, DMBA was injected directly into the prostate gland of male rats and after 14 days, rats received different amounts of puppet extract every 48 hours and by the end of day 21, intraperitoneal injection of puppet extract. In the control group, intraperitoneal injection of normal saline was performed. The results showed that the puppet extract significantly reduced prostate weight, especially at two concentrations (100 mg, 500, and 1000). Histopathological changes were also observed in the prostate tumors of p.alkekengi extract treated groups compared to the control group. It is suspected that the hydroalcoholic extract of the p.alkekengi inhibits abnormal growth, precancerous lesions, and DMBA-induced carcinoma in the BALB / c mouse prostate.