ﺗﺄﺛﯿﺮ ﻧﺎن ﻏﻨﯽ ﺷﺪه ﺑﺎ ﺧﺮﻓﻪ ﺑﺮ ﺑﯿﻤﺎران دﯾﺎﺑﺘﯽ ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﯿﮏ: ﯾﮏ ﮐﺎرآزﻣﺎﯾﯽ ﺑﺎﻟﯿﻨﯽ ﺗﺼﺎدﻓﯽ

Effect of Bread Fortified With Portulaca Oleracea on Diabetic Patients with Metabolic Syndrome: A Randomized Clinical Trial

ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﯿﮏ ﻣﺠﻤﻮﻋﻪاي ازﻋﻮاﻣﻞ ﻣﺘﺎﺑﻮﻟﯿﮏ ﻏﯿﺮﻃﺒﯿﻌﯽ اﺳﺖ ﮐﻪ اﻓﺮاد ﻣﺒﺘﻼ را در ﻣﻌﺮض ﺧﻄﺮ ﺑﯿﺸﺘﺮي ﺑﺮاي اﺑﺘﻼ ﺑﻪ ﺑﯿﻤﺎريﻫﺎي ﻗﻠﺒﯽﻋﺮوﻗﯽ، ﺳﮑﺘﻪ، ﭘﻮﮐﯽ اﺳﺘﺨﻮان، ﺳﺮﻃﺎن و اﻟﺘﻬﺎب را ﻗﺮار ﻣﯽدﻫﺪ. ﺧﺮﻓﻪ ﻧﻮﻋﯽ ﮔﯿﺎﻫﯽ ﻋﻠﻔﯽ اﺳﺖ ﮐﻪ ﺑﺮگﻫﺎي ﻏﻨﯽ از اﺳﯿﺪ ﻟﯿﻨﻮﻟﺌﯿﮏ دارد و ﻧﺎن ﺑﻪ ﻋﻨﻮان ﻗﻮت ﻏﺎﻟﺐ ﻣﺮدم ﺑﺴﺘﺮ ﻣﻨﺎﺳﺒﯽ ﺑﺮاي ﻏﻨﯽ ﺳﺎزي ﻣﯽﺑﺎﺷﺪ، ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﺑﺎ ﻫﺪف ﺗﺄﺛﯿﺮ ﻧﺎن ﻏﻨﯽﺷﺪه ﺑﺎ ﺧﺮﻓﻪ ﺑﺮ ﺑﯿﻤﺎران دﯾﺎﺑﺘﯽ ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﯿﮏ اﻧﺠﺎم ﺷﺪ. ﻣﻮاد و روشﻫﺎ: اﯾﻦ ﮐﺎرآزﻣﺎﯾﯽ ﺑﺎﻟﯿﻨﯽ ﺗﺼﺎدﻓﯽ ﻣﻮازي، ﺑﺮ روي 104 ﺑﯿﻤﺎر دﯾﺎﺑﺘﯽ ﻣﺒﺘﻼ ﺑﻪ ﺳﻨﺪرم ﻣﺘﺎﺑﻮﻟﯿﮏ اﻧﺠﺎم ﺷﺪ. ﺑﯿﻤﺎران ﺑﻪ دو ﮔﺮوه ﻣﺪاﺧﻠﻪ و ﺷﺎﻫﺪ ﺗﻘﺴﯿﻢ ﺷﺪﻧﺪ. ﮔﺮوه ﻣﺪاﺧﻠﻪ روزاﻧﻪ از ﻧﺎن ﻏﻨﯽﺷﺪه ﺑﺎ ﺧﺮﻓﻪ )%10( و ﮔﺮوه ﺷﺎﻫﺪ ﻧﺎن ﺑﺪون ﺧﺮﻓﻪ درﯾﺎﻓﺖ ﮐﺮدﻧﺪ. ﺑﺮاي ﺑﺮرﺳﯽ اﺛﺮ ﻣﺪاﺧﻠﻪ، اﺧﺘﻼف ﻣﯿﺎﻧﮕﯿﻦ ﻗﺒﻞ و ﺑﻌﺪ اﯾﻦ ﺷﺎﺧﺺﻫﺎ در دو ﮔﺮوه ﺑﺎ اﺳﺘﻔﺎده از آزﻣﻮن ﺗﯽ زوج اﻧﺠﺎم ﺷﺪه اﺳﺖ. ﻧﺘﺎﯾﺞ: ﻣﯿﺎﻧﮕﯿﻦ ﺳﻦ ﺷﺮﮐﺖﮐﻨﻨﺪﮔﺎن 53/6±6/5 ﺳﺎل و داﻣﻨﻪ ﺳﻦ ﺷﺮﮐﺖﮐﻨﻨﺪﮔﺎن ﺑﯿﻦ 33 ﺗﺎ 63 ﺳﺎل ﺑﻮد. ﻣﺮدان )%53 (51 ﻧﻔﺮ و زﻧﺎن )%51 (49 ﻧﻔﺮ از اﻓﺮاد ﻣﻮرد ﭘﮋوﻫﺶ را ﺷﺎﻣﻞ ﻣﯽﺷﺪﻧﺪ. ﺗﻌﺪاد 56 ﻧﻔﺮ )%53( اﻓﺮاد ﺷﺮﮐﺖ ﮐﻨﻨﺪه ﻣﺘﻮﺳﻂ ﺳﻦ اﺑﺘﻼ ﺑﻪ دﯾﺎﺑﺖ 2 ﺳﺎل ﺑﻮد، 56 ﻧﻔﺮ )53%/8( اﻓﺮاد ﺷﺮﮐﺖ ﮐﻨﻨﺪه داراي ﺳﻮاد دﺑﯿﺮﺳﺘﺎﻧﯽ و )49(8%/7 ﻧﻔﺮ ﺑﯿﺴﻮاد ﺑﻮدﻧﺪ. ﻧﺘﺎﯾﺞ ﻧﺸﺎن داد ﮐﻪ ﻗﺒﻞ از ﻣﺪاﺧﻠﻪ ﺗﻔﺎوت ﻣﻌﻨﯽداري ﺑﯿﻦ دو ﮔﺮوه از ﻟﺤﺎظ ﻣﯿﺎﻧﮕﯿﻦ ﻣﺘﻐﯿﺮﻫﺎي ﻣﻮرد ﺑﺮرﺳﯽ ﺑﺠﺰ ﻓﺸﺎرﺧﻮن دﯾﺎﺳﺘﻮﻟﯿﮏ )0/01

Metabolic syndrome is a set of abnormal metabolic factors that put people at greater risk for cardiovascular disease, stroke, osteoporosis, cancer and inflammation. The aim of this study was to evaluate the effect of portulaca enriched bread on diabetic patients with metabolic syndrome. Methods: This parallel randomized clinical trial was performed on 104 diabetic patients with metabolic syndrome. Patients were divided into intervention and control groups. The intervention group received daily portion of bread enriched with portulaca (10%) and the control group received bread without portulaca oleracea to evaluate the effect of the intervention, the difference between the mean before and after these indices in the two groups was performed using paired t-test. Results: The mean age of participants was 53.6. 6.5 years and the age range of participants were between 33 and 63 years. Men (51%) were 53 and women (49%) were 51 subjects. 56 (53%) participants had a mean age of 2 years of diabetes, 56 (53.8%) participants were high school literate and 49.8% were illiterate. The results showed that before the intervention, there was a significant difference in the mean of the studied variables except diastolic blood pressure (P <0.01) in other cases including (fasting blood sugar, waist, systolic blood pressure, triglyceride, HDL). Not observed between the two groups (P <0.05). Comparison of mean differences showed that in terms of FBS and total cholesterol, LDL, BPS after the intervention, a significant difference was observed between the two groups (P <0.05). Conclusion: The results showed that the consumption of bread enriched with portulaca oleracea, was able to reduce the components associated with metabolic syndrome and improved HDL cholesterol.