وﯾﮋﮔﯽ ﻫﺎي ﺑﺎﻟﯿﻨﯽ و آزﻣﺎﯾﺸﮕﺎﻫﯽ ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﻓﺸﺎرﺧﻮن ﺑﺴﺘﺮي ﺷﺪه در ﺑﯿﻤﺎرﺳﺘﺎن ﺑﻬﺎرﻟﻮ ﺗﻬﺮان ﺑﺎ ﺗﺸﺨﯿﺺ ﮐﻮﯾﺪ-19 و ارﺗﺒﺎط آن ﺑﺎ ﻣﺮگ و ﻣﯿﺮ آﻧﻬﺎ در ﺳﺎل 1399

Clinical and Laboratory Characteristics of Patients with Hypertension Admitted to Baharloo Hospital in Tehran with a Diagnosis of COVID-19 and Its Association with Mortality in 2020

اين مطالعه با هدف بررسي ويژگي‌هاي باليني و آزمايشگاهي بيماران مبتلا به فشارخون با تشخيص كويد-19 و ارتباط آن با مرگ انجام شده است. مواد و روش‌ها: اين مطالعه به‌صورت هم‌گروهي گذشته‌نگر و بر روي 341 بيمار مبتلا به فشار خون و كوويد-19 بستري شده در بيمارستان بهارلو انجام شد. اطلاعات بيماران در طول مدت بستري از خود بيماران و پرونده‌هاي پزشكي جمع‌آوري شد. رضايت آگاهانه‌ي خود بيماران يكي از شروط ورود ورود ﺑﯿﻤﺎران ﺑﻪ اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﻮد. ﺳﻄﺢ ﻣﻌﻨﺎداري ﺑﺮاي ﻫﻤﻪ ي ﺗﺠﺰﯾﻪ و ﺗﺤﻠﯿﻞ ﻫﺎ 5 درﺻﺪ در ﻧﻈﺮ ﮔﺮﻓﺘﻪ ﺷﺪ. ﻧﺘﺎﯾﺞ: ﺑﺮ اﺳﺎس ﻧﺘﺎﯾﺞ ﺑﻪ دﺳﺖ آﻣﺪه از اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﻣﯿﺰان ﻣﺮگ وﻣﯿﺮ اﯾﻦ ﺑﯿﻤﺎران 22% ﺑﻮده اﺳﺖ. دو ﮔﺮوه ﺑﻬﺒﻮد ﯾﺎﻓﺘﻪ و ﻓﻮت ﺷﺪه از ﻧﻈﺮ ﺳﻦ )P=0/044 (، ﻣﻘﺪار اﮐﺴﯿﮋن در ﺑﺪو ﺑﺴﺘﺮي )P=0/000 ( و ﺑﺴﺘﺮي ﺷﺪن درP=0/000) ICU ( اﺧﺘﻼف ﻣﻌﻨﺎدار داﺷﺘﻪ اﻧﺪ ﺑﻪ ﻃﻮري ﮐﻪ ﺑﯿﻤﺎران ﻓﻮت ﺷﺪه ﺑﻪ ﻃﻮر ﻣﯿﺎﻧﮕﯿﻦ 3/12 ﺳﺎل ﭘﯿﺮﺗﺮ ﺑﻮده، داراي 6/83 واﺣﺪ اﮐﺴﯿﮋن ﺧﻮن ﮐﻤﺘﺮ در ﻫﻨﮕﺎم ﺑﺴﺘﺮي و 69/3 درﺻﺪ ﺑﺴﺘﺮي ﺑﯿﺸﺘﺮ در ICU ﻧﺴﺒﺖ ﺑﻪ ﮔﺮوه ﺑﻬﺒﻮد ﯾﺎﻓﺘﻪ ﺑﻮدﻧﺪ. دو ﮔﺮوه زﻧﺪه ﻣﺎﻧﺪه و ﻓﻮت ﺷﺪه، از ﻧﻈﺮ ﻓﺎﮐﺘﻮرﻫﺎي ﺷﻤﺎرش ﮔﻠﺒﻮل ﻫﺎي ﺳﻔﯿﺪ ﺧﻮن )P=0/007 (، ﻟﻨﻔﻮﺳﯿﺖ )P=0/011 (، ﻧﻮﺗﺮوﻓﯿﻞ )P=0/000 (، ﭘﺮوﺗﯿﯿﻦ واﮐﻨﺸﯽ اﻟﺘﻬﺎﺑﯽ )P=0/000 (، ﻧﯿﺘﺮوژن اوره ﺧﻮن )P=0/001 (، ﮐﺮاﺗﯿﻨﯿﻦ ﺧﻮن )P=0/002 ( و ﻻﮐﺘﺎت دﻫﯿﺪروژﻧﺎز )P=0/000 ( ﺑﺎ ﻫﻢ اﺧﺘﻼف ﻣﻌﻨﺎدار داﺷﺘﻨﺪ. اﯾﻦ اﺧﺘﻼف ﺑﻪ ﻃﻮري ﺑﻮد ﮐﻪ اﻓﺮاد ﻓﻮت ﺷﺪه ﻟﻨﻔﻮﺳﯿﺖ و ﻧﻮﺗﺮوﻓﯿﻞ ﮐﻤﺘﺮ و CR ، BUN ، WBC ، CRP و LDH ﺑﯿﺸﺘﺮي ﻧﺴﺒﺖ ﺑﻪ اﻓﺮاد زﻧﺪه ﻣﺎﻧﺪه داﺷﺘﻨﺪ. ﻧﺘﯿﺠﻪ ﮔﯿﺮي: ﺑﺮاﺳﺎس ﻧﺘﺎﯾﺞ اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﻓﺸﺎرﺧﻮن داراي ﻣﯿﺰان ﻣﺮگ و ﻣﯿﺮ ﺑﺎﻻﺗﺮي ﻫﺴﺘﻨﺪ. اﻓﺮاد ﻓﻮت ﺷﺪه از ﻧﻈﺮ ﻓﺎﮐﺘﻮرﻫﺎي ﺗﻌﺪاد ﮔﻠﺒﻮل ﻫﺎي ﺳﻔﯿﺪ ﺧﻮن، ﻟﻨﻔﻮﺳﯿﺖ، ﻧﻮﺗﺮوﻓﯿﻞ، ﭘﺮوﺗﯿﯿﻦ واﮐﻨﺸﯽ اﻟﺘﻬﺎﺑﯽ، ﻧﯿﺘﺮوژن اوره ﺧﻮن، ﮐﺮاﺗﯿﻨﯿﻦ ﺧﻮن و ﻻﮐﺘﺎت دﻫﯿﺪروژﻧﺎز ﺑﺎ ﮔﺮوه زﻧﺪه ﻣﺎﻧﺪه اﺧﺘﻼف داﺷﺘﻨﺪ.

This study aimed to evaluate patients' clinical and laboratory characteristics with hypertension with the diagnosis of Covid-19 and its association with mortality. Methods: This retrospective cohort study was performed on 341 patients with hypertension and Covid-19 admitted to Baharloo Hospital. Patient information was collected from patients themselves and medical records during hospitalization. Patients' informed consent was one of the conditions for patients to enter this study. The significance level for all analyzes was considered 5%. Results: Based on this study's results, the mortality rate of these patients was 22%. The two groups of recovered and dead patients were significantly different in terms of age, oxygen level at admission, and admission to the ICU. The recovered and dead groups were different in terms of white blood cell count (WBC), lymphocyte, neutrophil, inflammatory reactive protein (CRP), blood urea nitrogen (BUN), blood creatinine (CR), and lactate dehydrogenase (LDH). The difference was that the deceased had fewer lymphocytes and neutrophils and more CRP, WBC, BUN, CR, and LDH than the survivors. Conclusion: Based on the results of this study, patients with hypertension have a higher mortality rate. The deceased differed from the surviving group in terms of white blood cell count, lymphocyte, neutrophil, inflammatory reactive protein, blood urea nitrogen, blood creatinine, and lactate dehydrogenase.