بررسي ارتباط اختلالات اسيد باز با پيش‌آگهي در بيماران مبتلابه مسموميت با الكل بستري در بيمارستان طالقاني اروميه

Evaluation of the Relationship between Open Acid Disorders and Prognosis in Patients with Alcohol Poisoning Admitted to Taleghani Hospital in Urmia

مسموميت حاد با الكل‌ها و شيوع اپيدمي‌ها در مناطق مختلف كشور جزو مهم‌ترين اورژانس‌هاي پزشكي شناخته‌شده كه همه‌ساله با عوارض و مرگ‌ومير بالا همراه مي‌باشند، اين مطالعه با هدف بررسي ارتباط اختلالات اسيد باز با پيش‌آگهي در بيماران مبتلابه مسموميت با الكل در بيمارستان طالقاني اروميه در سال 1398 انجام شد. مواد و روش‌ها: اين مطالعه به روش مقطعي در بازه زماني سال 1398 به روش سرشماري بر روي بيماران با مسموميت با الكل مراجعه‌كننده به بيمارستان طالقاني اروميه انجام شد، داده‌ها با استفاده از چك‌ليستي كه شامل اطلاعات دموگرافيك بود جمع‌آوري شد؛ داده‌ها بعد جمع‌آوري وارد SPSS شده و با كمكآﻣﺎر ﺗﻮﺻﯿﻔﯽ و آزﻣﻮن ﻫﺎي ﮐﺎي دو، ﺿﺮﯾﺐ ﻫﻤﺒﺴﺘﮕﯽ ﭘﯿﺮﺳﻮن، آزﻣﻮن ANOVA ، آزﻣﻮن T ﮔﺮوه ﻫﺎي ﻣﺴﺘﻘﻞ ﺗﺠﺰﯾﻪ وﺗﺤﻠﯿﻞ ﺷﺪ. ﻧﺘﺎﯾﺞ: ﻧﺘﺎﯾﺞ ﻧﺸﺎن داد از 234 ﺑﯿﻤﺎر ﺑﺴﺘﺮي در ﺑﯿﻤﺎرﺳﺘﺎن 91)213%( ﻣﺮد و 9)21%( زن ﺑﻮدﻧﺪ، ﺑﯿﺸﺘﺮﯾﻦ ﮔﺮوه ﺳﻨﯽ 21-30 ﺳﺎل ﺑﺎ 49/1)115%( ﺑﻮد، ﺑﯿﺸﺘﺮﯾﻦ ﺷﮑﺎﯾﺖ ﺑﯿﻤﺎران 38/8)91%( ﺗﻬﻮع و اﺳﺘﻔﺮاغ ﺑﻮده، ﻣﯿﺎﻧﮕﯿﻦ HCO3 4/42± 23/63 و ﻣﯿﺎﻧﮕﯿﻦ pH 0/08± 7/35 ﺑﻮد ﻋﺪم وﺟﻮد ﺗﻔﺎوت ﻣﻌﻨﺎدار ﺑﯿﻦ ﺟﻨﺴﯿﺖ ﺑﺎ ﻣﺴﻤﻮﻣﯿﺖ ﺑﺎ اﻟﮑﻞ )P=0/26 ( و اﺧﺘﻼﻻت اﺳﯿﺪ و ﺑﺎز ﺑﺎ ﺟﻨﺴﯿﺖ ﺑﻮد )P=0/24 ( ﺑﻮد. ﻧﯿﺎز داﺷﺘﻦ ﺑﻪ دﯾﺎﻟﯿﺰ ﯾﺎ ﻋﺪم ﻧﯿﺎز ﺑﻪ دﯾﺎﻟﯿﺰ ﺑﺎ ﻣﺴﻤﻮﻣﯿﺖ ﺑﺎ اﻟﮑﻞ راﺑﻄﻪ ﻣﻌﻨﺎدار داﺷﺖ )P=0/001 ( ﺑﯿﻦ اﺧﺘﻼﻻت اﺳﯿﺪ و ﺑﺎز ﺑﺎ ﭘﯿﺶ آﮔﻬﯽ ﺑﯿﻤﺎران ﻣﺴﻤﻮﻣﯿﺖ ﺑﺎ اﻟﮑﻞ ﻧﯿﺰ ارﺗﺒﺎط وﺟﻮد داﺷﺖ )P=0/001 (. ﻧﺘﯿﺠﻪ ﮔﯿﺮي: ﻧﺘﺎﯾﺞ ﻧﺸﺎن داد در ﻣﺴﻤﻮﻣﯿﺖ ﺑﺎ اﻟﮑﻞ، اﺧﺘﻼﻻت اﺳﯿﺪ ﺑﺎز ﺑﻪ وﯾﮋه اﺳﯿﺪوز ﻣﺘﺎﺑﻮﻟﯿﮏ ﺑﺎ ﭘﯿﺶ آﮔﻬﯽ ﺑﯿﻤﺎران ارﺗﺒﺎط ﻣﻌﻨﺎداري دارد و ﻫﻤﭽﻨﯿﻦ pH ﮐﻤﺘﺮ از 7/09 ﺑﺎ ﭘﯿﺶ آﮔﻬﯽ ﺿﻌﯿﻒ در ﺑﯿﻤﺎران ﻫﻤﺮاه ﻣﯽ ﺑﺎﺷﺪ. ﻫﺮﭼﻨﺪ ﺟﻬﺖ ﺗﺄﯾﯿﺪ ﻧﺘﺎﯾﺞ، ﻣﻄﺎﻟﻌﺎت ﺑﯿﺸﺘﺮ ﺑﺎ ﺣﺠﻢ ﻧﻤﻮﻧﻪ ﺑﺎﻻﺗﺮ و ﺑﺎ روش ﻣﻄﺎﻟﻌﻪ آﯾﻨﺪه ﻧﮕﺮ ﺗﻮﺻﯿﻪ ﻣﯽ ﮔﺮدد.

Acute alcohol poisoning and the spread of epidemics in different parts of the country are among the most important known medical emergencies that are associated with high morbidity and mortality every year. The aim of this study was to investigate the relationship between open acid disorders and prognosis in patients with alcohol poisoning in Taleghani Hospital in Urmia in 2019. Methods: This cross-sectional study was performed on patients with alcohol poisoning referred to Taleghani Hospital in Urmia during the period of 2019 by census method. The data were collected using a checklist that included demographic information. Data were collected by SPSS18 and analyzed using descriptive statistics and chi-square test, Pearson correlation coefficient, ANOVA test and independent group t-test. Results: The results showed that out of 234 patients admitted to the hospital, 213 (91%) were male and 21 (9%) were female. The highest age group was 21-30 years with 115 (49.1%). Nausea and vomiting, mean HCO3 was 23.63±4.42 and mean pH was 7.35±0.08, There was no significant difference between the sexes with alcohol poisoning (P=0.26) and acid and base disorders with sex (P=0.24). Need for dialysis or no need for dialysis was significantly associated with alcohol poisoning (P=0.001). There was also a relationship between acid and base disorders with the prognosis of patients with alcohol poisoning (P=0.001). Conclusion: The results showed that in alcohol poisoning, open acid disorders, especially metabolic acidosis, have a significant relationship with patients' prognosis and also pH less than 7.09 is associated with poor prognosis in patients. However, to confirm the results, more studies with higher sample size and prospective study method are recommended