بررسي تاثير داروي سيلوستازول بر نتايج حاصل از آنژيوپلاستي شرياني زير زانو در بيماران با ايسكمي اندام تحتاني مراجعه كننده به بخش جراحي عروق بيمارستان گلستان اهواز

Impact of Cilostazol on the Balloon Angioplasty for Infrapopliteal Artery Disease in Patients with Lower Limb Ischemia admitted to Vascular Surgery Ward of Ahwaz Golestan Hospital, Ahwaz City, Iran

مقدمه هدف از انجام مطالعه بررسي تاثير داروي سيلوستازول بر نتايج حاصل از آنژيوپلاستي شرياني زير زانو بود روش كار مطالعه به صورت كار آزمايي باليني تصادفي كنترل شده بر روي 50 بيمار كانديد بالون آنژيوپلاستي زير زانو انجام شد. بيماران در دو گروه 25 نفري به صورت تصادفي در دو گروه مصرف كننده پلاويكس به تنهايي (گروه A) و گروه مصرف كننده پلاويكس و سيلوستازول (گروه B) وارد مطالعه شدند و طي دوره 3 ماهه از نظر حفظ اندام، نياز به درمان اندوواسكولار مجدد ، بهبود علايم باليني و زخم ايسكميك و ميزان بروز عوارض مورد بررسي قرار گرفتند نتايج بيماران دو گروه از لحاظ مشخصات دموگرافيك و باليني با يكديگر تفاوت معنادار نداشتند (0/05P) ميزان نياز به مداخله جراحي در گروه A بيشتر از گروه B بود اما تفاوت معنادار نبود (0/05

Background and Objectives The study aimed to evaluate cilostazol's effects on balloon angioplasty for infrapopliteal artery disease. Subjects and Methods This randomized controlled clinical trial study was performed on 50 patients undergoing below-the-knee balloon angioplasty. The patients were randomly assigned into two groups: Plavix alone (Group A) and Plavix and cilostazol (Group B). During the 3 months, limb salvage, need for endovascular re-treatment, improvement of clinical symptoms, and incidence of adverse effects were compared between the two groups. Results There was no significant difference between the two groups regarding demographic and clinical characteristics (P >0.05). Significant improvements in symptoms were observed in group B. The improvements were seen in the rest pain and intermittent claudication within 3 months after treatment (P <0.05). The need for surgical intervention in group A was higher than in group B three months after treatment, but the difference was insignificant (P >0.05). None of the patients had reported heart failure within three months of treatment. Conclusion Although cilostazol administration after below-the-knee balloon angioplasty in patients with lower limb ischemia has a positive effect on improving symptoms such as rest pain and intermittent claudication, it did not show a positive effect on limb salvage, ischemic wound healing, and need for re-intervention. This study also showed no significant difference in cilostazol users with cardiac complications and gastrointestinal bleeding.