پديد آورندگان :
توكلي راد، فاطمه دانشگاه آزاد اسلامي واحد سنندج، سنندج، ايران , اكرادي، لقمان دانشگاه آزاد اسلامي واحد سنندج - گروه علوم درمانگاهي، سنندج، ايران , رئيس زاده، مهديه دانشگاه آزاد اسلامي واحد سنندج - گروه علوم پايه، سنندج، ايران
كليدواژه :
ترميم زخم , عصاره هل , خرگوش , آلوكسان
چكيده لاتين :
In this study, 30 male rabbits weighing 900 - 1000 g were randomly divided into 6 groups (positive control, negative control and test). After general anesthesia using a combination injection of ketamine 50 mg / kg and xylazine 5 mg / kg intraperitoneally to create ulcers in the rabbit skin a 10 mm circular punch was made. The wounds was measured with the aid of millimeter papers on the first, third, sixth, ninth, twelfth, fifteenth, eighteenth, and twenty-first days after surgery. This measurement is made at a specific time of day by a specific person. Complete recovery time was measured in negative, positive control and test samples. Then, on day 21, the wound was sampled. The specimens were subjected to histopathological studies after fixation of dewatering and staining.
According to the results, there was no significant difference between control group and T1 group (P <0.05), but there was a significant difference between control group and T2, T3, T4, T5 group (P <0.05). The highest difference was between T5 and control group. It can be said that methanolic extract of cardamom at a dose of 400 mg / kg topical and feeding on cardamom powder pellets was more effective than all groups. Also, migration of epithelial tissue and reduction of wound openings in group T5 on days 15 to 21 were higher than other groups. Also, cardamom powder as the last plate of food significantly decreased glucose in diabetic groups (P <0.05). Cardamom lowers blood sugar by antioxidants such as flanoids. According to the results of this study, cardamom extract has a high ability to heal full-thickness wounds compared to chemical drugs.
