ارتباط آنتي‌‌بادي‌هاي ضد‌هسته (ANA)‌، فاكتور روماتوئيد (RF) و آنتي‌بادي‌هاي ضد ‌سيترولينه حلقوي (Anti-CCP) با درصد و نوع درگيري ريوي در بيماران مبتلا به آرتريت روماتوئيد، بيمارستان بوعلي تهران (1399-1394)

Correlation between anti-nuclear antibodies (ANA), rheumatoid factor (RF), anti-cyclic citrullinated peptides antibodies (Anti-CCP) and percentage and type of pulmonary involvement in patients with rheumatoid arthritis, Booali Hospital Tehran (2016-2021)

يكي از شايع­ترين مشكلات خارج مفصلي در بيماري خود­ايمن و التهابي آتريت روماتوئيد (RA)، درگيري ريوي است. كنترل اين عارضه نقش موثري در ارتقاي كيفيت و افزايش زنده‌ماني بيماران دارد. هدف مطالعه، بررسي ارتباط فاكتورهاي التهابي بيماري با ميزان و نوع درگيري ريوي مبتلايان بود كه گام موثري در جهت تشخيص و درمان به­هنگام عارضه ريوي RA است. روش بررسي: در مطالعه­ حاضر تعداد 310 بيمار RA، با علايم مرتبط با درگيري ريوي در بيمارستان بوعلي تهران طي سال­هاي 1399-1394 موردبررسي قرار گرفتند. اطلاعات دموگرافيكي و فاكتور­هاي التهابي آنتي­بادي­هاي ضدهسته (ANA)، فاكتور روماتوئيد (RF) و آنتي­بادي­هاي ضد­سيترولينه­ي حلقوي(Anti-CCP) بيماران طي چهار ويزيت جداگانه ثبت شدند. تمامي بيماران تحت گرافي قفسهسينه و سي­تي­اسكن با رزولوشن بالا قرار گرفتند. پس از تاييد قطعي وجود/عدم­وجود درگيري ريوي، داده­ها با نرم­افزار SPSS21 و روش‌هاي آماري مناسب تحليل ﺷﺪﻧﺪ. ﺳﻄﺢ ﻣﻌﻨﯽداري 0/05

Controlling the pulmonary involvement, as one of the most common extra-articular consequences in rheumatoid arthritis (RA), can improve the life quality and survival rate of patients. This study aimed to evaluate the correlation between disease-related inflammatory factors and the severity and type of lung involvement in patients, which is a practical step toward early detection and treatment of RArelated pulmonary problems. Materials and methods: During 2016-2021, 310 RA patients with pulmonary involvement-related symptoms were studied at Booali Hospital in Tehran. During four separate visits, patients' demographic information and inflammatory factors such as anti-nuclear antibodies (ANA), rheumatoid factor (RF), and anti-cyclic citrulline antibodies (Anti-CCP) were assessed. High-resolution CT scans and chest radiographs were performed on all patients. Data were analyzed using SPSS21 software. P<0.05 was considered as the significance level. Results: Patients with and without pulmonary involvement had a mean age of 54±13 and 49±13 years, respectively. 35 patients (45.4%) had interstitial lung disease, 21 patients (27.2%) had pulmonary nodules, 3 patients (4%) had atelectasis, 11 patients (14.3%) had bronchitis, and 7 patients (9.1 %) had pulmonary fibrosis and emphysema. Correlation between anti-CCP and RF inflammatory factors and the prevalence and type of pulmonary involvement was significant (P<0.05). There was no statistically significant difference between the ANA index and demographic data among RA patients with pulmonary involvement. Conclusion: Inflammatory factors including anti-CCP and RF may help predict the severity and pulmonary complications prognosis in RA patients.