تداخل جنب منگنز با آهن

A STUDY OF THE INTERFERENCE OF MANGANESE ON INTESTINAL IRON ABSORPTION

Manganese is an essential trace element. This element is an important part of some metallo enzymes. There is little evidence for deficiency of manganese in humans , where as itʹs toxicity has been reported in several cases. There are a number of stages by which iron metabolism is achieved. The first stage is the uptake of iron from the lumen by intestinal mucosal cells. In mucosal cells, the exact mechanism by which iron transportation occurs is still a matter of speculation. It has been reported previously that manganese may interfere with iron metabolism either through intestinal absorption and / or via blood transportation sites which might be due to chemical similarities between these two metals. In this project , the inter relationship between iron (Fe) and manganese (Mn) absorptions in rat everted gut sac (EGS) has been investigated. Incubation of freshly prepared EGS in Krebbs ringer phosphate (KRP) Medium pH=7.4 containing either Fe(H) or Fe (HI) showed that iron absorption completed within 60 min of incubation time , whereas maximum manganese absorption occurred after 30 min. The absorption of metal Irons is a dose dependent process and maximum absorption occurs in the presence of 1.78 or 1.85 mM of iron and 1 or manganese respectively. Addition of iron to reaction mixture reduced manganese absorption significantly by 40% , while identical levels of manganese decreased iron absorption by approximately 15 precept. From the results of this study, it is concluded that both iron and manganese probably follow a sinilaw route of intestinal absorption such that iron has more priority than manganese.