ART در سيكلهاي )DET( ودو مرحله اي )SET( مقايسه نتايج انتقال جنين به دو روش يك مرحله اي

A COMPARITIVE STUDY OF "DET" AND "SET" AN ART CYCLES

The most important aim of ART is to increase implantation to physiological levels, the same as a normal cycle. For this aim, two methods are recommended; transfer of best quality embryos and increase in endometrium receptivity. Materials & Methods: A Clinical trial study was performed on 160 cycles of ART( IVF/ICSI) at the Research and Clinical Center of Infertility and Madar Hospital of Yazd. With this Supposition that two step embryo transfer may increase the endometrial receptivity, two groups were compared. Both groups were similar in respect to male age , female age and duration and cause of infertility. For Induction -Ovulation using Long Protocol, Buserelin was injected subcutaneousely, 0.5 cc daily from day 20 of menstrual cycle and the dose were decreased to 0.25 c` daily at start of menstrual bleeding. HMG (225 1U/day) was injected from day 2 of cycle. The measurement of follicle diameter was done serially. After HCG injection (10000IU) and ovarian puncture, the luteal phase was supported by progesterone injection. Then, the patients were divided randomly in two groups. The first group of 80patients had experienced two step embryo transfer on day 3, and on day 5, two or three embryos was transferred. In the control group of 80 patients, embryo transfer was done routinely 48hours after ovarian puncture. The patients were followed up by measurement of ISHCG serum level on day 14 after embryo transfer. Results: Two patients of first group and 14 patients of control group were left out from the study because of no follow up. The data was analyzed by chi-square and t test. Finally, there was no significant difference in pregnancy rate in the two groups. (P-Value= 1.000). Therefore, Two Step embryo transfer dose not increase the pregnancy rate more than one step embryo transfer. Conclusion: There was no significant difference between the two methods and pregnancy rate, number of embryos & pregnancy rate, the female age and pregnancy rate. However, further studies are needed in this field.