نقش كلونيدين خوراكي به عنوان پيش دارو جهت جلوگيري از لرزش بعد از بيهوشي عمومي

ROLE OF ORAL CLONIDINE AS A PREMEDIACANT FOR PREVENTION OF SHIVERING AFTER GENERAL ANAESTHESIA

Post operative shivering is one of the serious and important complications that may cause many problems including increase of myocardial oxygen requirement, production of cot and increase of minute ventilation leading to respiratory fatigue , increase in IOP and pain because of wound stretching. Clonidine is a a2 receptor agonist that is used as a premedicant to relieve mild pain and anxiety , prevention of salivation , nausea , vomiting, induction of hemodynamic stability and reduction of anesthetic requirement. There are some reports of anti shivering property of clonidine in recent studies.This study is a prospective double blind clinical trial to study the efficacy of clonidine on prevention of post-op shivering after general anesthesia. 100 patients condidated for elective surgery were divided in two equal study and control groups. Study group received oral clonidine, 0.2mg in 100m1 of water, 2hr befor surgery and control group received 100m1 of water as placebo. Shivering was marked as involuntary muscular activity and treated appropriately if necessary . 2 patients from study group (4%) and 11 patients from control group (22%) had shivering at the end of surgery (P=0.007). Comparison of shivering prevalence in the two groups reveals that oral clonidine as a premedicant decreases or prevents shivering after general anesthesia with no significant side effects in the mentioned dose.