بررسي پاسخ هاي ازدياد حساسيت تاخيري و توليد آنتي بادي متعاقب سوختگي در مدل حيواني موش

Evaluation of the Delayed type Hypersensitivity and Antibody Responses following Burn Injury in Mouse Animal Model

Infection remains the major cause of death following burn injury. This high rate of infection has been attributed to immune suppression. The aim of this study was to investigate the cell mediated and humoral immune responses following thermal injury in an animal model. Material and Methods: Male Balblc mice were anesthetized and given a 10% total body surface area full-thickness burn. The delayed type hypersensitivity (DTH) and humoral responses to sheep red blood cell (SRBC) were quantitated on different days of post burn. Results: We have demonstrated that marked suppression of DTH occurs during 30 days after burn trauma, with maximal suppression that occurring in 10 to 14 days after burn injury. Simultaneously the antibody response to SRBC was increased after thermal trauma. Discussion: These results show that severe alterations occur in DTH and antibody responses following burn injury. The severity of these changes varies at different times of post burn period. Moreover this study presents an ideal rodent model of burn exposure which can be used for further investigation in this area.