بر تون پايه وفعال آيورت سينه اي در موش صحرايي ديابتي )TRIGONELLA-F؟MUM-GRAECUM ( اثر تجويز درازمدت عصاره آبي برگ شنبليله

The Effect of Chronic Administration of Aqueous Leaf Extract of Trigonella foenum-graecum on the Basal and Active Tone of Aortic Rings in Diabetic Rats

Introduction: Considering the anti diabetic effect of fenugreek seed and leaf has become clear, this study was conducted to evaluate the effect of aqueous leaf extract of fenugreek on the basal and active tone of thoracic aorta in an experimental model of diabetes mellitus. Material & Methods: For the purpose of investigation, male Wistar rats were divided into control, extract-treated control, diabetic, and extract-treated diabetic groups. Fenugreek extract was administered at doses of 100 andlor 200 mg/Kg (i.p) every other day three days after the induction of diabetes for a period of 2 months. Body weight and serum glucose level were determined one week before the study and at 4th and 8th weeks after the experiment. In addition, after two months, thoracic aorta responsiveness under basal and active conditions was measured using isolated tissue setup.