كليدواژه :
Hypercalciuria , Urine chemistry , Kidney stone , سنگ سازي كليوي , هيپركلسيوري
چكيده لاتين :
Introduction: The origin of stone formation is super saturation and /or defect in crystallization inhibitors. Obtaining the results of a 24-hour urine collection is essential to the selection of the most appropriate intervention for preventing kidney stone recurrence. However, the recently accepted definitions of normal urine values are not firmly supported by the literature. In addition, availability of information about the relationship between risk of stone formation and the levels of urinary factors is of great importance.
Methods: According to exclusion and inclusion criteria, 144 subjects were selected for the study. Cases were patients with a history of passing more than 2 kidney stones (95 persons). Controls (49 persons) were patients with a history of passing one kidney stone in the past 2 years. The information was gathered. By the researcher for the history of passing kidney stone, the amount of protein taken during the week (eggs and meat), the results of the 24 hour urine collection including calcium, uric acid, exallat, Cytrate, Sodium, Phosphate, and volume and was registered in the questionnaire.
Results: Hypercalciuria, high level of urine Na, uric acid and phosphate excretion had significant relation with recurrent kidney stone (p=0.005, 0.049, 0.004 and 0.02 respectively). Hyperuricemia was inversely associated with recurrent renal stone. The risk of recurrent renal stone increased with urine calcium concentration (p=0.001) and hypercalciuric state in linear by linear association test (p=0.007).
Conclusion: The traditional definitions of normal 24-hour urine values may need to be reassessed, and their association with risk of stone formation may be continuous rather than dichotomous. 24 hour urine calculation for calcium, uric acid, sodium should be done for all patients with recurrent kidney stones and dietary recommendation of more water intake should be stressed.
